Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3787450 | 0.90 | ENPP2 (0.45) | ENPP2PTGS2EPHX2NR1H4EPHX1 | |
| SCHEMBL534070 | 0.83 | ENPP2 (0.39) | ENPP2PTGS2EPHX2NR1H4EPHX1 | |
| SCHEMBL3351536 | 0.83 | ITGB1 (0.41) | ENPP2PTGS2EPHX2NR1H4EPHX1 | |
| SCHEMBL15647871 | 0.81 | LDHA (0.55) | ENPP2PTGS2EPHX2NR1H4ITGB1 | |
| SCHEMBL3772833 | 0.80 | MMP8 (0.47) | ALDH1A1PTPRB | |
| SCHEMBL3785349 | 0.78 | EPHX2 (0.39) | ENPP2PTGS2EPHX2NR1H4EPHX1 | |
| SCHEMBL7274785 | 0.78 | MDM2 (0.53) | LMNA | |
| SCHEMBL4634327 | 0.77 | LMNA (0.42) | EPHX2ITGB1ITGA4MEN1ALDH1A1 | |
| SCHEMBL3783037 | 0.77 | ENPP2 (0.42) | ENPP2PTGS2EPHX2NR1H4EPHX1 | |
| SCHEMBL3351540 | 0.76 | ACE (0.43) | ENPP2PTGS2ITGB1ITGA4AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |