SCHEMBL33527314

SCHEMBL33527314

FC(F)(F)c1ccc2c(c1)Cc1cc(C(F)(F)F)ccc1-2

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TDP2 O95551 2/20 0.59
SLC1A3 P43003 1/20 0.48
SLC1A2 P43004 1/20 0.48
SLC1A1 P43005 1/20 0.48
ESR1 P03372 1/20 0.47
ESR2 Q92731 1/20 0.47
PNMT P11086 4/20 0.46
PARP1 P09874 1/20 0.46
PARP10 Q53GL7 1/20 0.46
GPR3 P46089 1/20 0.42
ALDH1A1 P00352 1/20 0.40
TSHR P16473 1/20 0.40
HTR2A P28223 3/20 0.40
HTR2C P28335 3/20 0.40
HTR2B P41595 3/20 0.40
KIF11 P52732 1/20 0.39
PTPN5 P54829 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL33527496 0.90 TDP2 (0.51) TDP2SLC1A3SLC1A2SLC1A1ESR1
Ammonia Solution, Strong SCHEMBL28002037 0.86 TDP2 (0.50) TDP2ESR1ESR2PNMTPARP1
Water SCHEMBL27598694 0.86 TDP2 (0.50) TDP2ESR1ESR2PNMTPARP1
SCHEMBL1479810 0.85 TDP2 (0.68) TDP2ESR1ESR2PARP10KIF11
SCHEMBL27974149 0.84 TDP2 (0.49) TDP2SLC1A3SLC1A2SLC1A1ESR1
SCHEMBL28634632 0.81 ALDH1A1 (0.48) TDP2PARP1PARP10GPR3ALDH1A1
SCHEMBL31265568 0.80 TDP2 (0.54) TDP2SLC1A3SLC1A2SLC1A1PNMT
SCHEMBL14593228 0.79 NR1H3 (0.44) TDP2ESR1ESR2TSHR
SCHEMBL7659930 0.77 KIF11 (0.47) TDP2PARP1PARP10GPR3HTR2A
SCHEMBL1482504 0.77 TDP2 (0.59) TDP2ESR1ESR2GPR3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260092028-A1 ONE-POT SYNTHESIS OF SUBSTITUTED FLOURENES CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2026-04-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092028-A1 ONE-POT SYNTHESIS OF SUBSTITUTED FLOURENES DYRK1B, DYRK2, DYRK4 TDP2 644/4885SLC1A3 1760/4885SLC1A2 1850/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.