Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | GRK6 | P43250 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 2/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3428421 | 0.89 | PPARD (0.39) | GSK3BPPARDPDE2APTGESPIM1 | |
| SCHEMBL3430772 | 0.85 | KDM4E (0.38) | GSK3BPTGES | |
| SCHEMBL3352967 | 0.83 | NR1D1 (0.40) | GSK3BPTGESPIM1PIM2 | |
| SCHEMBL3430623 | 0.83 | FFAR1 (0.43) | FFAR4FFAR1PPARDIDH1CYP2C9 | |
| SCHEMBL3430044 | 0.78 | FFAR1 (0.48) | FFAR4FFAR1PIM1PIM2GCGR | |
| SCHEMBL3430136 | 0.76 | DHODH (0.39) | PIM1PIM2DHODH | |
| SCHEMBL13580508 | 0.74 | FFAR4 (0.47) | FFAR4FFAR1PPARDCYP2C9CACNA1C | |
| SCHEMBL3349649 | 0.73 | FFAR1 (0.45) | FFAR4FFAR1PIM1PIM2GCGR | |
| SCHEMBL3431483 | 0.71 | FFAR1 (0.43) | FFAR4FFAR1PPARDPIM1PIM2 | |
| SCHEMBL12952588 | 0.71 | FFAR4 (0.49) | FFAR4FFAR1PPARDCYP2C9CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | claimed |
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | disclosed |