Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3430136 | 0.91 | DHODH (0.39) | KDM4EHSD17B10TP53MAPTALOX15 | |
| SCHEMBL3352922 | 0.85 | GSK3B (0.38) | GSK3BPTGES | |
| SCHEMBL3352967 | 0.84 | NR1D1 (0.40) | KDM4EHSD17B10MAPTGSK3BTRPV1 | |
| SCHEMBL3428421 | 0.82 | PPARD (0.39) | GSK3BPTGES | |
| SCHEMBL3346362 | 0.78 | DHODH (0.39) | KDM4EHSD17B10TRPV1TSHRALDH1A1 | |
| SCHEMBL3432976 | 0.78 | GSK3B (0.39) | KDM4EHSD17B10MAPTGSK3BTRPV1 | |
| SCHEMBL3344258 | 0.73 | KDM4E (0.43) | KDM4EHSD17B10MAPTGSK3BTRPV1 | |
| SCHEMBL3474513 | 0.69 | SCD (0.44) | TRPV1 | |
| SCHEMBL3430623 | 0.69 | FFAR1 (0.43) | KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL3430044 | 0.64 | FFAR1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | disclosed |