Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3357664 | 0.88 | HRH3 (0.47) | LMNAADRB2HTR1DHRH3ALDH1A1 | |
| SCHEMBL3355548 | 0.88 | HTR1D (0.48) | HTR6ADRB2HTR1DHTR2ASIGMAR1 | |
| SCHEMBL3356705 | 0.86 | HTR1D (0.47) | LMNAHTR6ADRB2HTR1DHTR2A | |
| SCHEMBL3355352 | 0.86 | ADRB2 (0.47) | HTR6ADRB2HTR1DHTR2ASIGMAR1 | |
| SCHEMBL27816681 | 0.81 | LMNA (0.62) | LMNAHTR2APOLBHTTALDH1A1 | |
| SCHEMBL3352554 | 0.79 | KMT2A (0.51) | LMNAHTR6POLBALDH1A1MAPT | |
| SCHEMBL3320875 | 0.78 | HTR1D (0.68) | HTR6ADRB2HTR1DHTR2AHTT | |
| SCHEMBL3358110 | 0.77 | HRH3 (0.55) | LMNAHRH3ALDH1A1MAPT | |
| SCHEMBL2075509 | 0.77 | HTR2A (0.44) | HTR6ADRB2HTR1DHTR2ASIGMAR1 | |
| SCHEMBL12005459 | 0.76 | SIGMAR1 (0.46) | SIGMAR1POLBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |