SCHEMBL335652

SCHEMBL335652

O=C(O)N1CC2CC1CN2

nearest known ligand 0.65

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 13/20 0.65
CHRNA4 P43681 13/20 0.65
CHRNA3 P32297 4/20 0.65
CHRNB3 Q05901 1/20 0.65
CHRNA6 Q15825 1/20 0.65
CHRNB4 P30926 3/20 0.37
CHRNA7 P36544 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL900113 1.00 CHRNB2 (0.65) CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6
SCHEMBL4058865 1.00 CHRNB2 (0.65) CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6
SCHEMBL2123406 1.00 CHRNB2 (0.65) CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6
SCHEMBL6339022 1.00 CHRNB2 (0.65) CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6
Hydrochloric Acid SCHEMBL23410453 0.98 CHRNB2 (0.62) CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6
Hydrochloric Acid SCHEMBL13518560 0.98 CHRNB2 (0.62) CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6
Hydrochloric Acid SCHEMBL16212072 0.98 CHRNB2 (0.62) CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6
SCHEMBL12356559 0.83 CHRNB2 (0.65) CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6
SCHEMBL1008776 0.83 CHRNB2 (0.65) CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6
SCHEMBL13050975 0.83 CHRNB2 (0.65) CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 270 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4182308-B1 PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS CHIESI FARM SPA (IT) 2024-09-04 EP claimed
CN-116867788-B 4-Aminoquinazoline compounds ASTELLAS PHARMA INC. (JP) 2026-05-26 CN disclosed
WO-2026087635-A1 DIHYDRO BENZOXAZINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2026-04-30 WO disclosed
US-20260070880-A1 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES, INC. (US) 2026-03-12 US disclosed
EP-4688783-A1 COMPOUNDS FOR DEGRADATION AND INHIBITION OF KRAS (G12D) PROTEIN Shenzhen Ionova Life Science Co., Ltd. (CN) 2026-02-11 EP disclosed
EP-4665718-A1 SMALL MOLECULES AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS, COMPOSITIONS AND USE THEREOF Apogee Pharmaceuticals, Inc. (CA) 2025-12-24 EP disclosed
US-20250304577-A1 TYK2 INHIBITORS BIOGEN MA INC. 2025-10-02 US disclosed
US-20250289830-A1 KRAS INHIBITORS ELI LILLY AND COMPANY 2025-09-18 US disclosed
EP-4572755-A2 CDK2 DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2025-06-25 EP disclosed
EP-4568675-A1 COMBINATION OF ANTICANCER AGENTS COMPRISING A BIFUNCTIONAL COMPOUND WITH G12D MUTANT KRAS INHIBITORY ACTIVITY Astellas Pharma Inc. (JP) 2025-06-18 EP disclosed
US-6492355-B1 Adamantane derivatives ASTRAZENECA AB (SE) 2002-12-10 US disclosed
EP-1242427-A1 NOVEL PIPERIDINE AND PIPERAZINE DERIVATIVES AstraZeneca AB (SE) 2002-09-25 EP disclosed
US-20020107235-A1 Glucocorticoid receptor modulators LIU KEVIN K (US) 2002-08-08 US disclosed
EP-1201649-A1 Glucocorticoid receptor modulators Pfizer Products Inc. (US) 2002-05-02 EP disclosed
EP-1171432-A1 ADAMANTANE DERIVATIVES AstraZeneca AB (SE) 2002-01-16 EP disclosed
WO-2001072751-A1 PYRROLOPYRIMIDINES AS TYROSINE KINASE INHIBITORS KNOLL GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 2001-10-04 WO disclosed
EP-1114053-A1 PYRROLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2001-07-11 EP disclosed
WO-2001046200-A1 NOVEL PIPERIDINE AND PIPERAZINE DERIVATIVES ASTRAZENECA AB (SE) 2001-06-28 WO disclosed
WO-2000061569-A1 ADAMANTANE DERIVATIVES ASTRAZENECA AB (SE) 2000-10-19 WO disclosed
WO-2000017203-A1 PYRROLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2000-03-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304577-A1 TYK2 INHIBITORS TYK2, JAK2, JAK1 CHRNB2 2015/4885CHRNA4 3854/4885CHRNA3 2921/4885
US-20260070880-A1 DYNAMIN ACTIVATORS DNM1, DNM1L, DNM2 CHRNB2 2734/4885CHRNA4 2239/4885CHRNA3 2206/4885
US-20250289830-A1 KRAS INHIBITORS KRAS, NRAS, HRAS CHRNB2 4853/4885CHRNA4 4868/4885CHRNA3 4833/4885
US-20020107235-A1 Glucocorticoid receptor modulators NR3C1, NR3C2, MC2R CHRNB2 2082/4885CHRNA4 1418/4885CHRNA3 1416/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.