Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.48 |
| ▸ | HTR7 | P34969 | 5/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 8/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3354280 | 0.90 | DRD2 (0.42) | HTR2AHTR7KCNH2DRD2GPR119 | |
| SCHEMBL3352334 | 0.90 | HTR2A (0.45) | HTR2AHTR7KCNH2DRD2GPR119 | |
| SCHEMBL3358945 | 0.85 | ALOX15 (0.52) | HTR2AHTR7KCNH2DRD2GPR119 | |
| SCHEMBL13537314 | 0.83 | HTR2A (0.49) | HTR2AHTR7KCNH2DRD2GPR119 | |
| SCHEMBL14923489 | 0.82 | CHEK1 (0.47) | HTR2AHTR7KCNH2DRD2GPR119 | |
| SCHEMBL3350441 | 0.80 | GLS (0.48) | HTR2AHTR7KCNH2DRD2GPR119 | |
| SCHEMBL3353482 | 0.80 | CHEK1 (0.42) | HTR2AHTR7KCNH2DRD2GPR119 | |
| SCHEMBL30271240 | 0.80 | CHEK1 (0.42) | HTR2AHTR7KCNH2DRD2GPR119 | |
| SCHEMBL3351511 | 0.80 | HTR1A (0.41) | HTR2AHTR7KCNH2DRD2GPR119 | |
| SCHEMBL29200978 | 0.78 | KDM4E (0.49) | GPR119ROCK1CHEK1AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |