Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4631036 | 0.95 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1CHRM2CHRM4 | |
| SCHEMBL30678342 | 0.95 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1CHRM2CHRM4 | |
| SCHEMBL4632488 | 0.88 | ALDH1A1 (0.63) | ALDH1A1KMT2AMEN1USP2CDK4 | |
| SCHEMBL29516976 | 0.88 | ALDH1A1 (0.63) | ALDH1A1KMT2AMEN1USP2CDK4 | |
| Ammonia Solution, Strong SCHEMBL28873729 | 0.86 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1USP2CDK4 | |
| SCHEMBL662301 | 0.82 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1CHRM2CHRM4 | |
| SCHEMBL4785056 | 0.78 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1CHRM2CHRM4 | |
| SCHEMBL5970702 | 0.78 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1CHRM2CHRM4 | |
| SCHEMBL19949789 | 0.78 | ADRA1D (0.42) | ALDH1A1KMT2AMEN1USP2CDK4 | |
| SCHEMBL12626929 | 0.77 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130469-A1 | 2, 6-NAPHTHRIDINE DERIVATIVES | VAN EIS MAURICE | 2010-05-27 | — | — | US | disclosed |
| EP-2144908-A1 | 2, 6-NAPHTHYRIDINE DERIVATIVES AS PROTEIN KINASE MODULATORS | Novartis Ag (CH) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008122614-A1 | 2, 6-NAPHTHYRIDINE DERIVATIVES AS PROTEIN KINASE MODULATORS | NOVARTIS AG (CH) | 2008-10-16 | — | — | WO | disclosed |
| EP-1859802-A2 | Compositions comprising benzo(G)quinoline derivates and prostaglandin derivates | Novartis AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| US-20070093507-A1 | Compositions comprising benzo (g) quinoline derivatives and prostaglandin derivatives | LAMBROU GEORGE N | 2007-04-26 | — | — | US | disclosed |
| EP-1663230-A1 | COMPOSITIONS COMPRISING BENZO(G)QUINOLINE DERIVATIVES AND PROSTAGLANDIN DERIVATIVES | Novartis AG (CH) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005023258-A1 | COMPOSITIONS COMPRISING BENZO (G) QUINOLINE DERIVATIVES AND PROSTAGLANDIN DERIVATIVES | NOVARTIS AG (CH) | 2005-03-17 | — | — | WO | disclosed |
| US-6080743-A | AS CHEMICAL INTERMEIDATES FOR PREPARING DRUGS | NOVARTIS AG (CH) | 2000-06-27 | — | — | US | disclosed |
| EP-0853617-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | Novartis AG (CH) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997008155-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | NOVARTIS AG (CH) | 1997-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130469-A1 | 2, 6-NAPHTHRIDINE DERIVATIVES | PKN1, PKN2, CDK9 | ALDH1A1 3883/4885KMT2A 1437/4885MEN1 1566/4885 |
| US-20070093507-A1 | Compositions comprising benzo (g) quinoline derivatives and prostaglandin derivatives | PTGIS, PTGES, PTGS2 | ALDH1A1 1871/4885KMT2A 3698/4885MEN1 3758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.