SCHEMBL3359339

SCHEMBL3359339

Cl[SiH2]C(Oc1ccccc1)Oc1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.39
TSHR P16473 1/20 0.39
CA4 P22748 1/20 0.36
ORAI1 Q96D31 1/20 0.35
ORAI2 Q96SN7 1/20 0.35
ORAI3 Q9BRQ5 1/20 0.35
TRPV6 Q9H1D0 1/20 0.35
SRC P12931 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
KMT2A Q03164 1/20 0.34
SLC6A4 P31645 2/20 0.33
PPARG P37231 2/20 0.33
PPARA Q07869 2/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
KDM4E B2RXH2 1/20 0.33
KCNA3 P22001 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A3 Q01959 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4354696 0.75 LTA4H (0.35) LTA4HTSHRCA4MEN1ALDH1A1
SCHEMBL705838 0.73 LTA4H (0.38) LTA4HTSHRCA4ALDH1A1SLC6A4
SCHEMBL704602 0.73 LTA4H (0.38) LTA4HTSHRCA4ALDH1A1SLC6A4
SCHEMBL705003 0.73 CA1 (0.40) LTA4HTSHRCA4SLC6A4PPARG
SCHEMBL15358854 0.70 LTA4H (0.45) LTA4HTSHRCA4MEN1ALDH1A1
SCHEMBL632465 0.70 LTA4H (0.45) LTA4HTSHRCA4MEN1ALDH1A1
SCHEMBL9319424 0.70 LTA4H (0.45) LTA4HTSHRCA4MEN1ALDH1A1
SCHEMBL4363429 0.70 KCNA3 (0.39) LTA4HTSHRALDH1A1SLC6A4PPARG
SCHEMBL705385 0.70 KCNA3 (0.39) LTA4HTSHRCA4ALDH1A1SLC6A4
SCHEMBL704372 0.70 KCNA3 (0.39) LTA4HTSHRCA4ALDH1A1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-63215701-A None JP disclosed
US-9475924-B2 Rubber composition for tire tread and pneumatic tire using the same THE YOKOHAMA RUBBER CO., LTD. (JP) 2016-10-25 US disclosed
US-20140206793-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2014-07-24 US disclosed
EP-2740759-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE Sumitomo Rubber Industries, Ltd. (JP) 2014-06-11 EP disclosed
EP-2177562-B1 Polymer, rubber composition and tire using the same SUMITOMO RUBBER IND (JP) 2014-05-14 EP disclosed
EP-2184318-B1 Rubber composition and tire SUMITOMO RUBBER IND (JP) 2014-03-19 EP disclosed
US-20130267646-A1 RUBBER COMPOSITION FOR TIRE TREAD AND PNEUMATIC TIRE USING THE SAME THE YOKOHAMA RUBBER CO., LTD. (JP) 2013-10-10 US disclosed
US-8431644-B2 Rubber composition and tire SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2013-04-30 US disclosed
EP-2182028-B1 Rubber composition and tire SUMITOMO RUBBER IND (JP) 2012-12-12 EP disclosed
EP-2184318-A2 Rubber composition and tire Sumitomo Rubber Industries, Ltd. (JP) 2010-05-12 EP disclosed
EP-2182028-A1 Rubber composition and tire Sumitomo Rubber Industries, Ltd. (JP) 2010-05-05 EP disclosed
US-20100105826-A1 RUBBER COMPOSITION AND TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2010-04-29 US disclosed
US-20100099795-A1 RUBBER COMPOSITION AND TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2010-04-22 US disclosed
US-20100099810-A1 POLYMER, RUBBER COMPOSITION AND TIRE USING THE SAME SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2010-04-22 US disclosed
EP-2177562-A2 Polymer, rubber composition and tire using the same Sumitomo Rubber Industries, Ltd. (JP) 2010-04-21 EP disclosed
JP-S63215701-A MANUFACTURE OF SILANE-COMPOUND MODIFIED RUBBERY POLYMER JAPAN SYNTHETIC RUBBER CO LTD 1988-09-08 JP disclosed