Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 13/20 | 0.58 |
| ▸ | DDO | Q99489 | 6/20 | 0.53 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3360150 | 0.88 | DAO (0.59) | DAODDOERCC1ERCC4GRIN2D | |
| SCHEMBL3362656 | 0.88 | DAO (0.61) | DAODDOERCC1ERCC4PGR | |
| SCHEMBL3361211 | 0.80 | DAO (0.53) | DAODDOGRIN2DGRIN3BGRIN1 | |
| SCHEMBL3424908 | 0.80 | DAO (0.53) | DAODDOALDH1A1HSD17B10KDM4E | |
| SCHEMBL3425539 | 0.78 | DAO (0.55) | DAODDOGRIN2DGRIN3BGRIN1 | |
| SCHEMBL3421760 | 0.78 | DAO (0.55) | DAODDOPGR | |
| SCHEMBL24136220 | 0.74 | IDO1 (0.36) | DAOGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3363264 | 0.73 | DAO (0.61) | DAODDOERCC1ERCC4GRIN2D | |
| SCHEMBL3395093 | 0.73 | DAO (0.67) | DAODDOGRIN2DGRIN3BGRIN1 | |
| SCHEMBL22394891 | 0.73 | IDO1 (0.65) | DAOGRIN1IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010058314-A1 | HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010058314-A1 | HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 2010-05-27 | — | — | WO | disclosed |