Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | HTR3A | P46098 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9054504 | 1.00 | AOC3 (0.65) | AOC3ADRA2AADRA1ATAAR1NFKB1 | |
| SCHEMBL7152554 | 1.00 | AOC3 (0.65) | AOC3ADRA2AADRA1ATAAR1NFKB1 | |
| Hydrochloric Acid SCHEMBL27911674 | 0.98 | AOC3 (0.62) | AOC3ADRA2AADRA1ATAAR1NFKB1 | |
| Acetic Acid SCHEMBL10672569 | 0.91 | AOC3 (0.56) | AOC3ADRA2AADRA1ATAAR1NFKB1 | |
| SCHEMBL6983701 | 0.84 | AOC3 (0.61) | AOC3ADRA2AADRA1ATAAR1MAPT | |
| SCHEMBL9298171 | 0.84 | AOC3 (0.61) | AOC3ADRA2AADRA1ATAAR1MAPT | |
| SCHEMBL327629 | 0.83 | AOC3 (0.63) | AOC3TSHRTDP1MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL6983699 | 0.82 | AOC3 (0.59) | AOC3ADRA2AADRA1ATAAR1MAPT | |
| SCHEMBL4074768 | 0.82 | TAAR1 (0.80) | ADRA2AADRA1ATAAR1NFKB1HTR3A | |
| SCHEMBL17660055 | 0.81 | AOC3 (0.61) | AOC3TSHRTDP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109180515-B | Synthetic method of N- [ 2-hydroxy-2- (4-methoxyphenyl) ethyl ] cinnamamide | 苏利制药科技江阴有限公司 | 2021-04-06 | — | — | CN | claimed |
| CN-109180515-A | A kind of synthetic method of N- [2- hydroxyl -2- (4- methoxyphenyl) ethyl] cinnamamide | 苏利制药科技江阴有限公司 | 2019-01-11 | — | — | CN | claimed |
| US-20220106327-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-07 | — | — | US | disclosed |
| CN-109734643-B | Method for synthesizing pyrroline compound by catalyzing amino alcohol and enol with iron | 陕西师范大学 | 2021-05-14 | — | — | CN | disclosed |
| CN-109180515-B | Synthetic method of N- [ 2-hydroxy-2- (4-methoxyphenyl) ethyl ] cinnamamide | 苏利制药科技江阴有限公司 | 2021-04-06 | — | — | CN | disclosed |
| CN-109734643-A | The method that iron catalytic amino alcohol synthesizes pyrrolines with enol | 陕西师范大学 | 2019-05-10 | — | — | CN | disclosed |
| CN-109180515-A | A kind of synthetic method of N- [2- hydroxyl -2- (4- methoxyphenyl) ethyl] cinnamamide | 苏利制药科技江阴有限公司 | 2019-01-11 | — | — | CN | disclosed |
| US-20160340305-A1 | DIRECT STEREOSPECIFIC SYNTHESIS OF UNPROTECTED AZIRIDINES FROM OLEFINS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-11-24 | — | — | US | disclosed |
| EP-1373167-B1 | SOLID PHASE SYNTHESIS SUPPORTS AND METHODS | 3M INNOVATIVE PROPERTIES CO (US) | 2015-12-09 | — | — | EP | disclosed |
| EP-2435019-B1 | DODECA-2E,4E-DIENE AMIDES AND THEIR USE AS MEDICAMENTS AND COSMETICS | WOLFF AUGUST GMBH & CO KG ARZNEIMITTEL DR (DE) | 2015-09-23 | — | — | EP | disclosed |
| US-20130289083-A1 | IDO Inhibitors | NEWLINK GENETICS CORPORATION | 2013-10-31 | — | — | US | disclosed |
| US-5128369-A | Antiallergens, bronchodilator agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-07-07 | — | — | US | disclosed |
| EP-0404197-A2 | Arylalkylamine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-12-27 | — | — | EP | disclosed |
| EP-0177326-B1 | 2-ARYLMETHYL-5-ARYL-OXAZOLIDINES, THEIR PREPARATION AND USE | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-17 | — | — | EP | disclosed |
| US-4782163-A | 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines | SMITHKLINE BECKMAN CORPORATION (US) | 1988-11-01 | — | — | US | disclosed |
| US-4705862-A | Chemical processes for 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)oxazolidines | SMITHKLINE BECKMAN CORPORATION (US) | 1987-11-10 | — | — | US | disclosed |
| EP-0177326-A2 | 2-Arylmethyl-5-aryl-oxazolidines, their preparation and use | SMITHKLINE BEECHAM CORPORATION (US) | 1986-04-09 | — | — | EP | disclosed |
| EP-0136016-A2 | N-(Substituted)-5-(substituted phenyl)-1,3-Oxazolidines: Herbicidal antidotes | STAUFFER CHEMICAL COMPANY (US) | 1985-04-03 | — | — | EP | disclosed |
| EP-0030030-A1 | Derivatives of 2-aminoethanol, processes for their preparation, pharmaceutical compositions containing such compounds and the use the latter | CIBA-GEIGY AG (CH) | 1981-06-10 | — | — | EP | disclosed |
| US-4010191-A | Acyl derivatives of substituted bis-arylalkylamino compounds | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DT) | 1977-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220106327-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | APOL1, PNLIP, APOB | AOC3 760/4885ADRA2A 3239/4885ADRA1A 1945/4885 |
| US-20160340305-A1 | DIRECT STEREOSPECIFIC SYNTHESIS OF UNPROTECTED AZIRIDINES FROM OLEFINS | AAAS, NISCH, HNMT | AOC3 5/4885ADRA2A 96/4885ADRA1A 99/4885 |
| US-20130289083-A1 | IDO Inhibitors | IDO1, IDO2, INMT | AOC3 1429/4885ADRA2A 1340/4885ADRA1A 1464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.