Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 3/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3357806 | 0.88 | DYRK1A (0.40) | ZAP70ERBB2EGFRHSP90AA1HSP90AB1 | |
| SCHEMBL3359250 | 0.86 | ZAP70 (0.53) | ZAP70 | |
| SCHEMBL3362708 | 0.81 | ZAP70 (0.49) | ZAP70 | |
| SCHEMBL3361858 | 0.81 | ZAP70 (0.47) | ZAP70 | |
| SCHEMBL3359095 | 0.79 | ZAP70 (0.45) | ZAP70EGFR | |
| SCHEMBL1050272 | 0.78 | ZAP70 (0.70) | ZAP70ERBB2EGFR | |
| SCHEMBL3360152 | 0.78 | ZAP70 (0.64) | ZAP70 | |
| SCHEMBL3359784 | 0.78 | ZAP70 (0.51) | ZAP70 | |
| SCHEMBL3362577 | 0.77 | DYRK1A (0.48) | ZAP70 | |
| SCHEMBL3359512 | 0.77 | ZAP70 (0.51) | ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |