Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 11/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 11/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL335500 | 0.87 | F9 (0.44) | RAB9ANPC1SMN1; SMN2KDR | |
| SCHEMBL334843 | 0.86 | KDR (0.45) | RAB9ANPC1SMN1; SMN2KDR | |
| SCHEMBL336071 | 0.86 | PYGL (0.45) | MAPTRAB9ANPC1TP53TSHR | |
| SCHEMBL335308 | 0.84 | MEN1 (0.44) | RXFP1RAB9ANPC1KDR | |
| SCHEMBL335946 | 0.83 | MMP2 (0.38) | MAPTRXFP1RAB9ANPC1TP53 | |
| SCHEMBL336586 | 0.81 | GRIN1 (0.44) | KDR | |
| SCHEMBL335420 | 0.80 | NPC1 (0.46) | MAPTRAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL15282285 | 0.80 | ACP1 (0.46) | MAPTRAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL15282212 | 0.80 | ACP1 (0.46) | MAPTRAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL335396 | 0.79 | F7 (0.44) | MAPTRAB9ANPC1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097758-B2 | Isoserine derivatives for use as coagulation factor IXa inhibitors | SANOFI-AVENTIS (FR) | 2012-01-17 | — | — | US | claimed |