Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 17/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 17/20 | 0.52 |
| ▸ | CASP1 | P29466 | 16/20 | 0.52 |
| ▸ | CASP7 | P55210 | 16/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 12/20 | 0.52 |
| ▸ | HPGD | P15428 | 9/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 13/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 11/20 | 0.46 |
| ▸ | GLA | P06280 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368105 | 0.91 | CHRNB2 (0.52) | CHRNB2CHRNA4ALDH1A1CYP1A2CASP1 | |
| SCHEMBL6705495 | 0.83 | ALDH1A1 (0.51) | CHRNB2CHRNA4ALDH1A1CYP1A2CASP1 | |
| SCHEMBL31398803 | 0.79 | CHRNB2 (0.56) | CHRNB2CHRNA4ALDH1A1CYP1A2CASP1 | |
| SCHEMBL3364374 | 0.79 | CHEK2 (0.42) | CHRNB2CHRNA4ALDH1A1CYP1A2CASP1 | |
| SCHEMBL18893696 | 0.74 | EGFR (0.49) | ALDH1A1CASP1CASP7HSD17B10TSHR | |
| SCHEMBL3366836 | 0.74 | PDGFRB (0.58) | CHRNB2CHRNA4ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL2921304 | 0.73 | ALDH1A1 (0.60) | CHRNB2CHRNA4ALDH1A1CYP1A2CASP1 | |
| SCHEMBL22638127 | 0.73 | CHRNB2 (0.56) | CHRNB2CHRNA4ALDH1A1CYP1A2CASP1 | |
| SCHEMBL29832175 | 0.72 | NCF1 (0.44) | CYP1A2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL872363 | 0.72 | ADRB1 (0.65) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309569-B1 | N-aryl-{4-[7-(alkoxy)quinazolin-4-yl]piperazinyl}carboxamide derivatives as PDGFRs inhibitors | MILLENNIUM PHARM INC (US) | 2010-10-06 | — | — | EP | disclosed |
| US-20060063770-A1 | Nitrogenous heterocyclic compounds | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-03-23 | — | — | US | disclosed |
| US-6956039-B2 | Nitrogenous heterocylic compounds | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-18 | — | — | US | disclosed |
| US-20040186110-A1 | Nitrogenous heterocylic compounds | MILLENNIUM PHARMACEUTICALS, INC. | 2004-09-23 | — | — | US | disclosed |
| EP-1309569-A2 | NITROGENOUS HETEROCYCLIC COMPOUNDS | Millennium Pharmaceuticals, Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002016362-A2 | NITROGENOUS HETEROCYCLIC COMPOUNDS | COR THERAPEUTICS, INC. (US) | 2002-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063770-A1 | Nitrogenous heterocyclic compounds | WNK2, CDK5, WNK1 | CHRNB2 4361/4885CHRNA4 4539/4885ALDH1A1 3521/4885 |
| US-20040186110-A1 | Nitrogenous heterocylic compounds | WNK2, CDK5, WNK1 | CHRNB2 4428/4885CHRNA4 4557/4885ALDH1A1 3312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.