Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3364253 | 0.86 | NR4A2 (0.41) | HRH4IMPDH2ELANETOP2ATUBB4A | |
| SCHEMBL3365869 | 0.84 | CYP3A4 (0.40) | HRH4SMN1; SMN2HSD17B10ALDH1A1HTT | |
| SCHEMBL3364109 | 0.79 | GABRG2 (0.41) | ALDH1A1POLB | |
| SCHEMBL3365166 | 0.78 | GABRG2 (0.42) | — | |
| SCHEMBL3362490 | 0.77 | HRH4 (0.40) | HRH4IMPDH2ELANETOP2ATUBB4A | |
| SCHEMBL3367042 | 0.77 | DHODH (0.41) | GAALMNASMN1; SMN2PDE10AUSP2 | |
| SCHEMBL3363948 | 0.77 | GPR35 (0.40) | TOP2ATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3368049 | 0.76 | DHODH (0.41) | — | |
| SCHEMBL3365574 | 0.75 | BRD4 (0.47) | GPR84LMNASMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL3367559 | 0.73 | PRNP (0.38) | HRH4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656353-B1 | GABANERGIC MODULATORS | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | claimed |
| US-7365211-B2 | Heterocyclic GABAA subtype selective receptor modulators | ROCHE PALO ALTO LLC (US) | 2008-04-29 | — | — | US | disclosed |