Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.46 |
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15282381 | 0.85 | SRD5A1 (0.64) | HTTSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL2601324 | 0.77 | METAP1 (0.60) | HTTSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL4068688 | 0.76 | SRD5A1 (0.55) | HTTSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL31029247 | 0.76 | CASP1 (0.59) | HTTSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL4706442 | 0.76 | METAP1 (0.53) | HTTSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL28603 | 0.76 | CASP1 (0.59) | HTTSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL18281237 | 0.74 | PARP10 (0.50) | HTTSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL3369293 | 0.73 | CYP11B2 (0.46) | SRD5A1CYP19A1CYP11B1CYP11B2PARP1 | |
| SCHEMBL15395916 | 0.72 | METAP1 (0.50) | HTTSRD5A1SRD5A2CYP19A1CYP11B1 | |
| SCHEMBL4041916 | 0.72 | HTT (0.50) | HTTSRD5A1SRD5A2CYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716132-B1 | SPIRO-BENZODIOXOLES AND THEIR USE AS CB1 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-08-25 | — | — | EP | disclosed |
| US-7144890-B2 | Spiro-pentacyclic compounds | HOFFMAN-LA ROCHE INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20050165012-A1 | Spiro-pentacyclic compounds | HOFFMANN-LA ROCHE INC. | 2005-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165012-A1 | Spiro-pentacyclic compounds | CNR1, CNR2, GPR119 | HTT 2709/4885SRD5A1 285/4885SRD5A2 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.