Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11876381 | 0.81 | TRPA1 (0.48) | TRPA1ALDH1A1CYP3A4MIFHPGD | |
| SCHEMBL1326974 | 0.79 | TAAR1 (0.44) | TRPA1ALDH1A1CYP3A4MIFHPGD | |
| SCHEMBL2098954 | 0.76 | NOS2 (0.45) | TRPA1ALDH1A1CYP3A4MIFHPGD | |
| SCHEMBL3934527 | 0.74 | MIF (0.45) | TRPA1ALDH1A1CYP3A4MIFHPGD | |
| SCHEMBL7871906 | 0.74 | MIF (0.45) | TRPA1ALDH1A1CYP3A4MIFHPGD | |
| SCHEMBL8136632 | 0.74 | TAAR1 (0.42) | TRPA1ALDH1A1CYP3A4MIFHPGD | |
| SCHEMBL94934 | 0.68 | LMNA (0.38) | TRPA1ALDH1A1MIFTP53TAAR1 | |
| SCHEMBL8926501 | 0.68 | ESR1 (0.39) | TRPA1ALDH1A1CYP3A4MIFHPGD | |
| Ethylbenzene SCHEMBL27526815 | 0.67 | TP53 (0.74) | TRPA1TP53TAAR1SIGMAR1SLC6A2 | |
| SCHEMBL2145 | 0.67 | ALDH1A1 (0.50) | TRPA1ALDH1A1CYP3A4MIFHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4954499-A | Pyridazinone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-09-04 | — | — | US | claimed |
| US-20100324091-A1 | Pyrazolone Derivative | KOWA COMPANY, LTD. (JP) | 2010-12-23 | — | — | US | disclosed |
| EP-2172458-A1 | PYRAZOLONE DERIVATIVE | Kowa Company, Ltd. (JP) | 2010-04-07 | — | — | EP | disclosed |
| US-4954499-A | Pyridazinone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-09-04 | — | — | US | disclosed |
| US-4688059-A | 3-ARYL(OR HETEROARYL)-3-(OXY OR THIO)PHTHALIDE AS REAGENT IN CARBONLESS DUPLICATING SYSTEM | THE HILTON-DAVIS CHEMICAL CO. (US) | 1987-08-18 | — | — | US | disclosed |
| US-4661605-A | CARBONLESS CUPLICATION AND THERMAL MARKING SYSTEMS | THE HILTON-DAVIS CHEMICAL CO. (US) | 1987-04-28 | — | — | US | disclosed |
| US-4535172-A | FOR CARBONLESS DUPLICATING AND THERMAL MARKING SYSTEMS | THE HILTON-DAVIS CHEMICAL CO. (US) | 1985-08-13 | — | — | US | disclosed |
| US-4528136-A | Process for preparing 2-[bis(aryl)methyl]benzoic acids | THE HILTON-DAVIS CHEMICAL CO. (US) | 1985-07-09 | — | — | US | disclosed |
| US-4399291-A | CONDENSATION OF A BENZALDEHYDE, AN ANILINE, AN AMINOBENZOIC ACID; OXIDATION | STERLING DRUG INC. (US) | 1983-08-16 | — | — | US | disclosed |
| EP-0082394-A2 | A process for the production of aminophthalides and amino benzoic acids | STERLING DRUG INC. (US) | 1983-06-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324091-A1 | Pyrazolone Derivative | SERPINE1, SERPINC1, TFPI | TRPA1 929/4885ALDH1A1 517/4885CYP3A4 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.