Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | GOT1 | P17174 | 2/20 | 0.58 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346412 | 0.81 | CNR1 (0.53) | MC4R | |
| SCHEMBL3346376 | 0.80 | MC4R (0.63) | MC4RNPC1RAB9AALDH1A1POLB | |
| SCHEMBL3348201 | 0.76 | CNR1 (0.54) | MC4RRAB9AALDH1A1PKMPOLB | |
| SCHEMBL2226816 | 0.76 | MC4R (0.68) | MC4RALDH1A1TSHR | |
| SCHEMBL4394464 | 0.75 | MTNR1A (0.90) | MC4RMEN1KMT2AHTR1AMTNR1A | |
| SCHEMBL3346481 | 0.74 | KCNH2 (0.47) | MC4RMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL3347924 | 0.74 | TAAR1 (0.52) | MC4RALDH1A1LMNAPOLB | |
| SCHEMBL3350700 | 0.73 | ROCK2 (0.42) | MC4RALDH1A1 | |
| SCHEMBL3346908 | 0.73 | MAPT (0.48) | MC4RMEN1KMT2ANPC1RAB9A | |
| SCHEMBL3353041 | 0.73 | CNR1 (0.55) | MC4RALDH1A1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |