Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730326 | 0.78 | POLB (0.48) | ALDH1A1MAPTPOLBMEN1HPGD | |
| SCHEMBL3066458 | 0.76 | POLB (0.46) | ALDH1A1MAPTPOLBMEN1HPGD | |
| SCHEMBL7329716 | 0.75 | L3MBTL1 (0.42) | ALDH1A1MAPTPOLBHSP90AA1L3MBTL1 | |
| SCHEMBL4915413 | 0.75 | ALDH1A1 (0.34) | ALDH1A1MAPTPOLBMEN1HPGD | |
| SCHEMBL10722261 | 0.74 | GSK3B (0.52) | ALDH1A1MAPTPOLBMEN1HPGD | |
| SCHEMBL11377643 | 0.74 | HDAC1 (0.42) | ALDH1A1MAPTPOLBHSP90AA1L3MBTL1 | |
| SCHEMBL6374349 | 0.74 | ALDH1A1 (0.41) | ALDH1A1MAPTPOLBMEN1HPGD | |
| SCHEMBL2389975 | 0.74 | ATM (0.50) | ALDH1A1MAPTPOLBMEN1HPGD | |
| SCHEMBL11009208 | 0.74 | ALDH1A1 (0.52) | ALDH1A1MAPTPOLBMEN1HPGD | |
| SCHEMBL3077851 | 0.74 | ALDH1A1 (0.41) | ALDH1A1MAPTPOLBMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311960-A1 | Phosphinoamidite Carboxylates and Analogs Thereof in the Synthesis of Oligonucleotide Having Reduced Internucleotide Charge | LIEVRE CORNU LLC (US) | 2010-12-09 | — | — | US | claimed |
| US-7745591-B2 | phosphinocarboxylate and phosphonocarboxylate oligonucleotides having enhanced nuclease resistance | Lievre Cornu, LLC (US) | 2010-06-29 | — | — | US | claimed |
| US-7427679-B2 | Precursors for two-step polynucleotide synthesis | AGILENT TECHNOLOGIES, INC. (US) | 2008-09-23 | — | — | US | claimed |
| US-7417139-B2 | Method for polynucleotide synthesis | AGILENT TECHNOLOGIES, INC. (US) | 2008-08-26 | — | — | US | claimed |
| US-7385050-B2 | Cleavable linker for polynucleotide synthesis | AGILENT TECHNOLOGIES, INC. (US) | 2008-06-10 | — | — | US | claimed |
| US-7193077-B2 | Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis | AGILENT TECHNOLOGIES, INC. (US) | 2007-03-20 | — | — | US | claimed |
| EP-1334111-A4 | PHOSPHINOAMIDITE CARBOXYLATES AND ANALOGS THEREOF IN THE SYNTHESIS OF OLIGONUCLEOTIDES HAVING REDUCED INTERNUCLEOTIDE CHARGE | DELLINGER DOUGLAS J (US) | 2007-01-24 | — | — | EP | claimed |
| US-20060293511-A1 | phosphinocarboxylate and phosphonocarboxylate oligonucleotides having enhanced nuclease resistance | LIEVRE CORNU LLC (US) | 2006-12-28 | — | — | US | claimed |
| US-7067641-B2 | Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge | LIEVRE CORNU LLC (US) | 2006-06-27 | — | — | US | claimed |
| US-20050048601-A1 | Method for polynucleotide synthesis | REGENTS OF THE UNIVERSITY OF COLORADO, THE | 2005-03-03 | — | — | US | claimed |
| US-20050049407-A1 | Precursors for two-step polynucleotide synthesis | THE REGENTS OF THE UNIVERSITY OF COLORADO | 2005-03-03 | — | — | US | claimed |
| US-20050048497-A1 | Cleavable linker for polynucleotide synthesis | THE REGENTS OF THE UNIVERSITY OF COLORADO | 2005-03-03 | — | — | US | claimed |
| EP-1510523-A1 | Precurors for two-step polynucleotide synthesis | Agilent Technologies Inc (US) | 2005-03-02 | — | — | EP | claimed |
| EP-1334111-A2 | PHOSPHINOAMIDITE CARBOXYLATES AND ANALOGS THEREOF IN THE SYNTHESIS OF OLIGONUCLEOTIDES HAVING REDUCED INTERNUCLEOTIDE CHARGE | Dellinger, Douglas J. (US) | 2003-08-13 | — | — | EP | claimed |
| WO-2002032912-A2 | PHOSPHINOAMIDITE CARBOXYLATES AND ANALOGS THEREOF IN THE SYNTHESIS OF OLIGONUCLEOTIDES HAVING REDUCED INTERNUCLEOTIDE CHARGE | DELLINGER DOUGLAS J (US) | 2002-04-25 | — | — | WO | claimed |
| WO-2024006953-A2 | MONOMERS AND METHODS FOR SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES | ALNYLAM PHARMACEUTICALS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |
| US-8097711-B2 | nucleoside monomers protected with thioether substituted aryl carbonate protecting groups; oligonucleotides, using such protected nucleoside monomer monomers, as well as nucleic acids | AGILENT TECHNOLOGIES, INC. (US) | 2012-01-17 | — | — | US | disclosed |
| US-6693187-B1 | ENHANCING NUCLEASE RESISTANCE | LIEVRE CORNU LLC | 2004-02-17 | — | — | US | disclosed |
| EP-1334111-A2 | PHOSPHINOAMIDITE CARBOXYLATES AND ANALOGS THEREOF IN THE SYNTHESIS OF OLIGONUCLEOTIDES HAVING REDUCED INTERNUCLEOTIDE CHARGE | Dellinger, Douglas J. (US) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002032912-A2 | PHOSPHINOAMIDITE CARBOXYLATES AND ANALOGS THEREOF IN THE SYNTHESIS OF OLIGONUCLEOTIDES HAVING REDUCED INTERNUCLEOTIDE CHARGE | DELLINGER DOUGLAS J (US) | 2002-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050048601-A1 | Method for polynucleotide synthesis | POLN, RNGTT, NSUN2 | ALDH1A1 4398/4885MAPT 4158/4885POLB 27/4885 |
| US-20100311960-A1 | Phosphinoamidite Carboxylates and Analogs Thereof in the Synthesis of Oligonucleotide Having Reduced Internucleotide Charge | NSUN2, POLL, DUT | ALDH1A1 3034/4885MAPT 4836/4885POLB 47/4885 |
| US-20050049407-A1 | Precursors for two-step polynucleotide synthesis | NT5C3B, NSUN2, POLN | ALDH1A1 4145/4885MAPT 4124/4885POLB 12/4885 |
| US-20050048497-A1 | Cleavable linker for polynucleotide synthesis | TYMP, POLN, CPSF1 | ALDH1A1 4036/4885MAPT 4176/4885POLB 26/4885 |
| US-20060293511-A1 | phosphinocarboxylate and phosphonocarboxylate oligonucleotides having enhanced nuclease resistance | NSUN2, ADAR, POLL | ALDH1A1 3420/4885MAPT 4867/4885POLB 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.