Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 11/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385668 | 0.87 | RET (0.47) | RETNTRK1AURKAMAP4K4CSF1R | |
| SCHEMBL3386105 | 0.82 | ALDH1A1 (0.52) | KDRFLT3 | |
| SCHEMBL3381138 | 0.77 | KDR (0.42) | RETKDRMAPK14ERBB2MAPK11 | |
| SCHEMBL3383188 | 0.76 | FLT3 (0.48) | RETNTRK1KDRMAPK14FLT3 | |
| SCHEMBL3385590 | 0.76 | MAPK14 (0.40) | NTRK1KDRMAPK14FLT3 | |
| SCHEMBL3385883 | 0.76 | KDR (0.50) | KDRMAPK14ERBB2MAPK11 | |
| SCHEMBL3382710 | 0.74 | MAPK14 (0.60) | RETNTRK1KDRMAPK14ERBB2 | |
| SCHEMBL3383429 | 0.73 | FLT3 (0.48) | RETNTRK1KDRMAPK14FLT3 | |
| SCHEMBL3381778 | 0.73 | LOXL2 (0.59) | KDRFLT3 | |
| SCHEMBL3384012 | 0.72 | KDR (0.53) | RETNTRK1KDRMAPK14ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |