Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.38 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL271766 | 0.83 | IDO1 (0.52) | TP53ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL16235297 | 0.82 | PSEN1 (0.53) | ALDH1A1MEN1KMT2ACYP3A4IDO1 | |
| SCHEMBL2375264 | 0.82 | CSNK2A1 (0.40) | TP53ALDH1A1MCL1MEN1KMT2A | |
| SCHEMBL13321612 | 0.82 | CYP3A4 (0.41) | TP53ALDH1A1MCL1MEN1KMT2A | |
| SCHEMBL2375257 | 0.82 | TP53 (0.39) | TP53ALDH1A1MCL1MEN1KMT2A | |
| SCHEMBL14378225 | 0.80 | FLT1 (0.42) | TP53ALDH1A1MCL1MEN1KMT2A | |
| SCHEMBL271289 | 0.80 | IDO1 (0.37) | ALDH1A1KMT2AIDO1HPGDMAPT | |
| SCHEMBL5696976 | 0.80 | POLB (0.39) | TP53ALDH1A1MCL1MEN1KMT2A | |
| SCHEMBL27536511 | 0.80 | FLT1 (0.40) | TP53ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL16046605 | 0.80 | PSEN1 (0.47) | ALDH1A1MEN1KMT2ACYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3126329-B1 | N-HYDROXYMETHANESULFONAMIDE NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS INC (US) | 2019-05-29 | — | — | EP | disclosed |
| US-10125125-B2 | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB (SE) | 2018-11-13 | — | — | US | disclosed |
| US-20180155330-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2018-06-07 | — | — | US | disclosed |
| US-9932303-B2 | N-hydroxymethanesulfonamide nitroxyl donors | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2018-04-03 | — | — | US | disclosed |
| US-9873687-B2 | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | ACTIVE BIOTECH AB (SE) | 2018-01-23 | — | — | US | disclosed |
| EP-3126329-A1 | N-HYDROXYMETHANESULFONAMIDE NITROXYL DONORS | Cardioxyl Pharmaceuticals Inc. (US) | 2017-02-08 | — | — | EP | disclosed |
| US-20160115158-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2016-04-28 | — | — | US | disclosed |
| US-20160046569-A1 | N-HYDROXYMETHANESULFONAMIDE NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS, INC. | 2016-02-18 | — | — | US | disclosed |
| EP-2925743-B1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2016-02-03 | — | — | EP | disclosed |
| EP-2925743-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | Active Biotech AB (SE) | 2015-10-07 | — | — | EP | disclosed |
| WO-2015109210-A1 | N-HYDROXYMETHANESULFONAMIDE NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2015-07-23 | — | — | WO | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |
| EP-1933835-B1 | TETRAHYDRO-PYRROLO[1,2-B]ISOTHIAZOLE 1,1-DIOXIDES AS LFA-1 INHIBITORS | NOVARTIS AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| US-20080242710-A1 | Pharmaceutically Active Tetrahydro-Pyrrolo[1,2-B]Isothiazole 1,1-Dioxides | BAUMANN KARL | 2008-10-02 | — | — | US | disclosed |
| EP-1933835-A1 | PHARMACEUTICALLY ACTIVE TETRAHYDRO-PYRROLO[1,2-B]ISOTHIAZOLE 1,1-DIOXIDES | Novartis AG (CH) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007039616-A1 | PHARMACEUTICALLY ACTIVE TETRAHYDRO-PYRROLO[1,2-B]ISOTHIAZOLE 1,1-DIOXIDES | NOVARTIS AG (CH) | 2007-04-12 | — | — | WO | disclosed |
| WO-1994018165-A1 | SULFONAMIDE COMPOUNDS AS OPIOID K-RECEPTOR AGONISTS | PFIZER INC. (US) | 1994-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10125125-B2 | N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors | S100A9, S100B, S100A10 | TP53 226/4885ALDH1A1 4109/4885MCL1 3215/4885 |
| US-20080242710-A1 | Pharmaceutically Active Tetrahydro-Pyrrolo[1,2-B]Isothiazole 1,1-Dioxides | ICAM1, VCAM1, SELPLG | TP53 1066/4885ALDH1A1 57/4885MCL1 181/4885 |
| US-20180155330-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | S100A9, S100B, S100A10 | TP53 226/4885ALDH1A1 4109/4885MCL1 3215/4885 |
| US-20160046569-A1 | N-HYDROXYMETHANESULFONAMIDE NITROXYL DONORS | TNNI3, TNNC1, TNNT2 | TP53 1977/4885ALDH1A1 2178/4885MCL1 2375/4885 |
| US-20160115158-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | S100A9, S100A4, S100B | TP53 207/4885ALDH1A1 4370/4885MCL1 2207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.