SCHEMBL339112

SCHEMBL339112

Oc1cc(Cl)ccc1-c1ccc(Cl)cc1O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 6/20 0.65
TSHR P16473 5/20 0.65
ALDH1A1 P00352 4/20 0.65
CYP3A4 P08684 3/20 0.65
TDP1 Q9NUW8 1/20 0.65
HSP90AA1 P07900 4/20 0.56
HPGD P15428 6/20 0.52
ALOX15 P16050 3/20 0.52
ALOX12 P18054 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
MAPK1 P28482 1/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
MEN1 O00255 2/20 0.50
HTT P42858 2/20 0.50
KMT2A Q03164 2/20 0.50
HIF1A Q16665 2/20 0.50
LMNA P02545 2/20 0.50
MAPT P10636 2/20 0.50
HSPA5 P11021 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL665598 0.89 HSD17B10 (0.61) HSD17B10TSHRALDH1A1CYP3A4TDP1
Water SCHEMBL7522925 0.87 HSD17B10 (0.58) HSD17B10TSHRALDH1A1CYP3A4TDP1
SCHEMBL22078332 0.87 HSD17B10 (0.52) HSD17B10TSHRALDH1A1CYP3A4TDP1
SCHEMBL22375221 0.85 HSD17B10 (0.50) HSD17B10TSHRALDH1A1CYP3A4TDP1
SCHEMBL22737967 0.85 HSD17B10 (0.50) HSD17B10TSHRALDH1A1CYP3A4TDP1
SCHEMBL24264582 0.83 HSD17B10 (0.48) HSD17B10TSHRALDH1A1CYP3A4TDP1
SCHEMBL29405140 0.81
SCHEMBL70036 0.81
SCHEMBL21668964 0.80 CA9 (0.50) HSD17B10TSHRALDH1A1CYP3A4TDP1
SCHEMBL23693567 0.80 HSD11B1 (0.47) HSD17B10TSHRALDH1A1CYP3A4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2271651-B1 ISOTHERMAL PROCESS FOR PHOSPHOROMONOCHLORIDITE SYNTHESIS DOW GLOBAL TECHNOLOGIES LLC (US) 2014-01-01 EP disclosed
EP-2346887-B1 SLURRY PROCESS FOR SYNTHESIS OF BISPHOSPHITES DOW TECHNOLOGY INVESTMENTS LLC (US) 2013-12-25 EP disclosed
US-8546600-B2 Slurry process for synthesis of bisphosphites and situ use thereof for producing bisphosphite DOW TECHNOLOGY INVESTMENTS LLC 2013-10-01 US disclosed
EP-2257560-B1 SLURRY PROCESS FOR PHOSPHOROMONOCHLORIDITE SYNTHESIS UNION CARBIDE CHEM PLASTIC (US) 2013-07-17 EP disclosed
US-8471066-B2 Slurry process for phosphoromonochloridite synthesis UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY LLC 2013-06-25 US disclosed
US-8097749-B2 Isothermal process for phosphoromonochloridite synthesis Union Carbide Chemical and Plastics Technology Technology 2012-01-17 US disclosed
EP-1348716-B1 Aromatic polymer, method for producing the same and uses thereof SUMITOMO CHEMICAL CO (JP) 2011-10-12 EP disclosed
US-20110196166-A1 SLURRY PROCESS FOR SYNTHESIS OF BISPHOSPHITES AND SITU USE THEREOF FOR PRODUCING BISPHOSPHITE DOW TECHNOLOGY INVESTMENTS LLC 2011-08-11 US disclosed
EP-2346887-A1 SLURRY PROCESS FOR SYNTHESIS OF BISPHOSPHITES Dow Technology Investments LLC (US) 2011-07-27 EP disclosed
US-20110021840-A1 SLURRY PROCESS FOR PHOSPHOROMONOCHLORIDITE SYTHESIS UNION CARBIDE CORPORATION 2011-01-27 US disclosed
EP-2271651-A1 ISOTHERMAL PROCESS FOR PHOSPHOROMONOCHLORIDITE SYNTHESIS Dow Global Technologies Inc. (US) 2011-01-12 EP disclosed
EP-2257560-A1 SLURRY PROCESS FOR PHOSPHOROMONOCHLORIDITE SYNTHESIS Union Carbide Chemicals & Plastics Technology Llc (Formerly Union Carbide Chemicals & Plastics Technology Corporation) (US) 2010-12-08 EP disclosed
WO-2010042313-A1 SLURRY PROCESS FOR SYNTHESIS OF BISPHOSPHITES DOW TECHNOLOGY INVESTMENTS LLC (US) 2010-04-15 WO disclosed
WO-2009120529-A1 SLURRY PROCESS FOR PHOSPHOROMONOCHLORIDITE SYNTHESIS UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY LLC (FORMERLY UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION) (US) 2009-10-01 WO disclosed
WO-2009120210-A1 ISOTHERMAL PROCESS FOR PHOSPHOROMONOCHLORIDITE SYNTHESIS DOW GLOBAL TECHNOLOGIES INC. (US) 2009-10-01 WO disclosed
US-20090247790-A1 ISOTHERMAL PROCESS FOR PHOSPHOROMONOCHLORIDITE SYNTHESIS UNION CARBIDE CORPORATION 2009-10-01 US disclosed
US-7285616-B2 Aromatic polymer, method for producing the same and uses thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-10-23 US disclosed
EP-1348716-A1 Aromatic polymer, method for producing the same and uses thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-10-01 EP disclosed
US-20030180596-A1 Aromatic polymer, method for producing the same and uses thereof SUMITOMO CHEMICAL COMPANY, LIMITED 2003-09-25 US disclosed
US-4366171-A Fungicidal biphenyl esters, mixtures thereof and method of use GAF CORPORATION (US) 1982-12-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090247790-A1 ISOTHERMAL PROCESS FOR PHOSPHOROMONOCHLORIDITE SYNTHESIS PIM3, PLCB3, PLCD1 HSD17B10 1022/4885TSHR 3388/4885ALDH1A1 4149/4885
US-20110196166-A1 SLURRY PROCESS FOR SYNTHESIS OF BISPHOSPHITES AND SITU USE THEREOF FOR PRODUCING BISPHOSPHITE SOST, PLCB3, PPIP5K2 HSD17B10 3843/4885TSHR 4332/4885ALDH1A1 4653/4885
US-20110021840-A1 SLURRY PROCESS FOR PHOSPHOROMONOCHLORIDITE SYTHESIS PSPH, SPIN3, SYNGR2 HSD17B10 3135/4885TSHR 4683/4885ALDH1A1 4865/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.