Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BCL9 | O00512 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4758273 | 0.81 | CNR1 (0.39) | LMNAMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10874214 | 0.78 | TDP1 (0.38) | TDP1LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL4755372 | 0.78 | TSHR (0.39) | TDP1LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL7429615 | 0.76 | TDP1 (0.37) | TDP1LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL4756165 | 0.75 | TP53 (0.43) | TDP1LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4883866 | 0.74 | TP53 (0.43) | TDP1ATMLMNAMAPTALDH1A1 | |
| SCHEMBL9826311 | 0.74 | CYSLTR2 (0.40) | LMNAMAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4758254 | 0.72 | HCAR3 (0.39) | TDP1LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4756162 | 0.72 | TDP1 (0.40) | TDP1LMNAALDH1A1KMT2A | |
| SCHEMBL28409208 | 0.71 | TDP1 (0.45) | TDP1SRD5A2LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229167-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | Merck Sharp & Dohme Corp. (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009078934-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2009-06-25 | — | — | WO | disclosed |