SCHEMBL4756162

SCHEMBL4756162

CCN1C(C)=C(C(=O)O)C(CC)(c2cccc(F)c2)C(C(=O)O)=C1C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.40
HCAR2 Q8TDS4 1/20 0.39
ALDH1A1 P00352 1/20 0.38
SLC6A2 P23975 1/20 0.38
SLC6A4 P31645 1/20 0.38
CCR2 P41597 1/20 0.38
GRIN2B Q13224 2/20 0.37
LMNA P02545 1/20 0.36
HSD11B1 P28845 1/20 0.36
NOTUM Q6P988 1/20 0.36
OPRM1 P35372 1/20 0.35
OPRL1 P41146 1/20 0.35
GSK3A P49840 1/20 0.35
GSK3B P49841 1/20 0.35
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
TSHR P16473 1/20 0.34
KMT2A Q03164 1/20 0.34
MC4R P32245 1/20 0.33
MC5R P33032 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4758299 0.85 LMNA (0.42) TDP1HCAR2ALDH1A1SLC6A4LMNA
SCHEMBL4758254 0.85 HCAR3 (0.39) TDP1HCAR2ALDH1A1SLC6A2SLC6A4
SCHEMBL4758337 0.84 HSD11B1 (0.36) HCAR2CCR2HSD11B1NOTUMOPRM1
SCHEMBL4758575 0.78 OPRM1 (0.39) SLC6A2SLC6A4CCR2NOTUMOPRM1
SCHEMBL4755316 0.76 HCAR2 (0.36) HCAR2ALDH1A1LMNANOTUMTSHR
SCHEMBL4758583 0.76 PYGL (0.38) TDP1ALDH1A1LMNANOTUMTSHR
SCHEMBL4757333 0.76 OPRM1 (0.36) ALDH1A1CCR2NOTUMOPRM1TSHR
SCHEMBL4757340 0.76 NOTUM (0.34) CCR2NOTUM
SCHEMBL10874214 0.73 TDP1 (0.38) TDP1ALDH1A1SLC6A2LMNATSHR
SCHEMBL4758577 0.72 TSHR (0.36) ALDH1A1LMNANOTUMTSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008006070-A2 COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF ROSKAMP RESEARCH LLC (US) 2008-01-10 WO disclosed
EP-1858325-A2 COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS Roskamp Research LLC (US) 2007-11-28 EP disclosed
WO-2006074419-A2 COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS ROSKAMP RESEARCH LLC (US) 2006-07-13 WO disclosed