Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 9/20 | 0.59 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3393091 | 0.85 | PYCR1 (0.67) | PYCR1SLC6A4ALDH1A1TSHRMAOB | |
| SCHEMBL13074386 | 0.82 | SLC6A4 (0.57) | PYCR1PRMT6SLC6A4SLC6A3ACHE | |
| SCHEMBL13070308 | 0.81 | PRMT6 (0.51) | PRMT6SLC6A4SLC6A3ACHEALDH1A1 | |
| SCHEMBL17917641 | 0.80 | PRMT6 (0.50) | PRMT6SLC6A4SLC6A3ACHEALDH1A1 | |
| SCHEMBL13070310 | 0.79 | ACHE (0.49) | PYCR1PRMT6SLC6A4SLC6A3ACHE | |
| SCHEMBL31612503 | 0.78 | PRMT6 (0.48) | PRMT6SLC6A4SLC6A3ACHEALDH1A1 | |
| SCHEMBL14376138 | 0.77 | ACHE (0.53) | PRMT6SLC6A4SLC6A3ACHEALDH1A1 | |
| SCHEMBL3396909 | 0.77 | SLC6A4 (0.56) | PYCR1SLC6A4SLC6A3ACHEALDH1A1 | |
| SCHEMBL2056224 | 0.76 | SLC6A4 (0.66) | PRMT6SLC6A4SLC6A3ALDH1A1TSHR | |
| SCHEMBL3394463 | 0.75 | PYCR1 (0.47) | PYCR1SLC6A4SLC6A3TSHRMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |