SCHEMBL339503

SCHEMBL339503

C=Cc1cc(Cl)c(Cl)cc1OC(C)C

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CSNK2A1 P68400 2/20 0.39
RORC P51449 1/20 0.35
MDM2 Q00987 2/20 0.34
ALDH1A1 P00352 2/20 0.33
MEN1 O00255 1/20 0.33
LMNA P02545 1/20 0.33
KMT2A Q03164 1/20 0.33
GAA P10253 1/20 0.32
S1PR1 P21453 1/20 0.32
S1PR3 Q99500 1/20 0.32
KDM4E B2RXH2 1/20 0.31
POLB P06746 1/20 0.31
HPGD P15428 1/20 0.31
TSHR P16473 1/20 0.31
HSD17B10 Q99714 1/20 0.31
SCN9A Q15858 1/20 0.30
IRAK4 Q9NWZ3 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL340235 0.78 SCN9A (0.33) ALDH1A1SCN9A
SCHEMBL340634 0.78 MDM2 (0.40) CSNK2A1RORCMDM2ALDH1A1MEN1
SCHEMBL7583020 0.75 PPOX (0.40) CSNK2A1RORCALDH1A1MEN1LMNA
SCHEMBL13019313 0.74 CSNK2A1 (0.50) CSNK2A1RORCALDH1A1MEN1LMNA
SCHEMBL16309559 0.74 IRAK4 (0.49) MDM2ALDH1A1MEN1KMT2AKDM4E
SCHEMBL13257964 0.72 P2RX3 (0.39) CSNK2A1ALDH1A1LMNAGAAPOLB
SCHEMBL6935704 0.72 ALDH1A1 (0.41) MDM2ALDH1A1LMNAKMT2AKDM4E
SCHEMBL19121709 0.72 CSNK2A1 (0.38) CSNK2A1MDM2MEN1LMNAKMT2A
SCHEMBL28417064 0.71 ALDH1A1 (0.50) ALDH1A1HPGDTSHRHSD17B10
SCHEMBL24996926 0.70 ALDH1A1 (0.37) CSNK2A1MDM2ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8288576-B2 Recyclable ruthenium catalysts for metathesis reactions ZANNAN SCITECH CO., LTD. (CN) 2012-10-16 US disclosed
US-20120016093-A1 RECYCLABLE RUTHENIUM CATALYSTS FOR METATHESIS REACTIONS ZANNAN SCITECH CO., LTD. (CN) 2012-01-19 US disclosed
US-8049025-B2 Recyclable ruthenium catalysts for metathesis reactions ZANNAN SCITECH CO., LTD. (CN) 2011-11-01 US disclosed
US-20100041844-A1 RECYCLABLE RUTHENIUM CATALYSTS FOR METATHESIS REACTIONS ZHENG-YUN JAMES ZHAN (CN) 2010-02-18 US disclosed
US-7632772-B2 Recyclable ruthenium catalysts for metathesis reactions Zhan, Zheng-Yun James (CN) 2009-12-15 US disclosed
US-20070043180-A1 Recyclable ruthenium catalysts for metathesis reactions ZHENG-YUN JAMES ZHAN (CN) 2007-02-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120016093-A1 RECYCLABLE RUTHENIUM CATALYSTS FOR METATHESIS REACTIONS RPIA, REV1, RCSD1 CSNK2A1 4050/4885RORC 3451/4885MDM2 587/4885
US-20100041844-A1 RECYCLABLE RUTHENIUM CATALYSTS FOR METATHESIS REACTIONS RPIA, REV1, RCSD1 CSNK2A1 4050/4885RORC 3451/4885MDM2 587/4885
US-20070043180-A1 Recyclable ruthenium catalysts for metathesis reactions RPIA, REV1, RCSD1 CSNK2A1 4050/4885RORC 3451/4885MDM2 587/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.