Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755372 | 0.91 | TSHR (0.39) | TDP1TSHRL3MBTL1MAPTALDH1A1 | |
| SCHEMBL3392997 | 0.76 | TDP1 (0.40) | TDP1L3MBTL1MAPTALDH1A1MEN1 | |
| SCHEMBL4757355 | 0.75 | PYGM (0.39) | CRHBPCRHR2ALDH1A1CYP2C19LMNA | |
| SCHEMBL4755316 | 0.75 | HCAR2 (0.36) | TSHRALDH1A1MEN1KMT2ARECQL | |
| SCHEMBL4758299 | 0.73 | LMNA (0.42) | TDP1TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL11390110 | 0.72 | TDP1 (0.37) | TDP1L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL9826311 | 0.69 | CYSLTR2 (0.40) | CRHBPCRHR2MAPTALDH1A1KMT2A | |
| SCHEMBL6385093 | 0.69 | TPMT (0.35) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL7429615 | 0.68 | TDP1 (0.37) | TDP1TSHRL3MBTL1MAPTALDH1A1 | |
| SCHEMBL4880017 | 0.68 | TSHR (0.38) | TDP1TSHRL3MBTL1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229167-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | Merck Sharp & Dohme Corp. (US) | 2010-09-22 | — | — | EP | claimed |
| WO-2009078934-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2009-06-25 | — | — | WO | claimed |