Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | PYGM | P11217 | 5/20 | 0.34 |
| ▸ | PYGL | P06737 | 4/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089394 | 0.83 | APP (0.41) | LMNARECQLKMT2AHTTALDH1A1 | |
| SCHEMBL4758299 | 0.81 | LMNA (0.42) | HCAR2LMNAPYGMPYGLKMT2A | |
| SCHEMBL4755372 | 0.80 | TSHR (0.39) | LMNAKMT2AGAATSHRALDH1A1 | |
| SCHEMBL9832820 | 0.80 | LMNA (0.30) | LMNAPYGMPYGL | |
| SCHEMBL4758577 | 0.79 | TSHR (0.36) | LMNAPYGMPYGLNOTUMKMT2A | |
| SCHEMBL4757320 | 0.74 | HCAR2 (0.39) | HCAR2LMNANOTUMGAATSHR | |
| SCHEMBL4758273 | 0.72 | CNR1 (0.39) | LMNAKMT2AGAAALDH1A1CNR1 | |
| SCHEMBL4084609 | 0.71 | PRNP (0.40) | LMNAPYGMPYGLKMT2AALDH1A1 | |
| SCHEMBL5533759 | 0.70 | KDM4E (0.39) | LMNAKMT2AGAATSHRHTT | |
| SCHEMBL4758575 | 0.69 | OPRM1 (0.39) | NOTUMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006070-A2 | COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF | ROSKAMP RESEARCH LLC (US) | 2008-01-10 | — | — | WO | disclosed |
| EP-1858325-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | Roskamp Research LLC (US) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006074419-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | ROSKAMP RESEARCH LLC (US) | 2006-07-13 | — | — | WO | disclosed |