Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14065652 | 0.83 | SENP1 (0.36) | BRD4HSD17B10SLC2A1 | |
| SCHEMBL3396240 | 0.82 | IKBKB (0.35) | BRD4HSD17B10SLC2A1 | |
| SCHEMBL14065459 | 0.73 | SLC2A1 (0.40) | BRD4HSD17B10SLC2A1 | |
| SCHEMBL3425836 | 0.69 | CYP11B1 (0.37) | BRD4CYP2A6HSD17B10SLC2A1 | |
| SCHEMBL3558780 | 0.69 | SCN9A (0.40) | SLC2A1 | |
| SCHEMBL13439218 | 0.69 | TLR8 (0.42) | SLC2A1 | |
| SCHEMBL9264323 | 0.67 | SLC2A1 (0.60) | BRD4HSD17B10SLC2A1 | |
| SCHEMBL9265685 | 0.66 | SLC2A1 (0.62) | BRD4HSD17B10SLC2A1 | |
| SCHEMBL26106365 | 0.65 | CYP2A6 (0.56) | BRD4CYP2A6HSD17B10 | |
| SCHEMBL9266330 | 0.65 | TYMP (0.50) | SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |