Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | MC3R | P41968 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1462053 | 0.86 | — | — | |
| SCHEMBL31671034 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL27792154 | 0.84 | NNMT (0.42) | NNMTKMT2ALMNAP2RX7ADORA3 | |
| Bromide SCHEMBL27792171 | 0.84 | NNMT (0.42) | NNMTKMT2ALMNAP2RX7ADORA3 | |
| SCHEMBL31519524 | 0.84 | NNMT (0.42) | NNMTKMT2ALMNAP2RX7ADORA3 | |
| Oxalic Acid SCHEMBL27792142 | 0.80 | NNMT (0.40) | NNMTKMT2ALMNAP2RX7ADORA3 | |
| Trifluoroacetic Acid SCHEMBL27741907 | 0.78 | L3MBTL1 (0.38) | NNMTKMT2AADORA3TSHRMC4R | |
| SCHEMBL27813478 | 0.76 | NNMT (0.41) | NNMTP2RX7ADORA3TSHRMC4R | |
| Tromethamine SCHEMBL11209439 | 0.75 | MEN1 (0.39) | KMT2AMEN1LMNA | |
| Tromethamine SCHEMBL6235066 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754787-B2 | Curable film-forming compositions containing colloidal particle sols having improved appearance and mar and scratch resistance | PPG INDUSTRIES OHIO, INC. (US) | 2010-07-13 | — | — | US | disclosed |
| US-20090062461-A1 | CURABLE FILM-FORMING COMPOSITIONS CONTAINING COLLOIDAL SOLS HAVING IMPROVED APPEARANCE AND MAR AND SCRATCH RESISTANCE | PPG INDUSTRIES OHIO, INC. (US) | 2009-03-05 | — | — | US | disclosed |