Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539378 | 0.72 | MEN1 (0.36) | — | |
| Tromethamine SCHEMBL3398947 | 0.72 | NNMT (0.35) | — | |
| Tromethamine SCHEMBL11209439 | 0.71 | MEN1 (0.39) | — | |
| SCHEMBL27419554 | 0.69 | LMNA (0.36) | — | |
| Tromethamine SCHEMBL7793673 | 0.68 | — | — | |
| SCHEMBL27725288 | 0.66 | THRB (0.38) | — | |
| Tromethamine SCHEMBL1683967 | 0.66 | LOXL2 (0.35) | — | |
| SCHEMBL10665799 | 0.65 | ALDH1A1 (0.38) | — | |
| SCHEMBL27696080 | 0.65 | KMT2A (0.42) | — | |
| SCHEMBL29165581 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274762-B1 | POLYCARBONATE PREPARATION PROCESS | DOW GLOBAL TECHNOLOGIES INC (US) | 2005-05-11 | — | — | EP | claimed |
| EP-1274762-A1 | POLYCARBONATE PREPARATION PROCESS | THE DOW CHEMICAL COMPANY (US) | 2003-01-15 | — | — | EP | claimed |
| WO-2001077204-A1 | POLYCARBONATE PREPARATION PROCESS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2001-10-18 | — | — | WO | claimed |
| US-6225436-B1 | REACTING PHOSGENE AND DIHYDRIC PHENOL; ADDING ACYL HALIDE; ADDING A CHAIN TERMINATOR TO THE REACTION MIXTURE; COMPLETING POLYMERIZATION REACTION | THE DOW CHEMICAL COMPANY | 2001-05-01 | — | — | US | claimed |
| EP-1274762-B1 | POLYCARBONATE PREPARATION PROCESS | DOW GLOBAL TECHNOLOGIES INC (US) | 2005-05-11 | — | — | EP | disclosed |
| EP-1274762-A1 | POLYCARBONATE PREPARATION PROCESS | THE DOW CHEMICAL COMPANY (US) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001077204-A1 | POLYCARBONATE PREPARATION PROCESS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2001-10-18 | — | — | WO | disclosed |
| US-6225436-B1 | REACTING PHOSGENE AND DIHYDRIC PHENOL; ADDING ACYL HALIDE; ADDING A CHAIN TERMINATOR TO THE REACTION MIXTURE; COMPLETING POLYMERIZATION REACTION | THE DOW CHEMICAL COMPANY | 2001-05-01 | — | — | US | disclosed |