Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | ACE | P12821 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | APAF1 | O14727 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.59 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.59 |
| ▸ | ITGAL | P20701 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399085 | 1.00 | ALOX15 (0.62) | ALOX15ACESMN1; SMN2KDM4EMAPT | |
| SCHEMBL30782236 | 0.85 | ALOX15 (0.70) | ALOX15ACESMN1; SMN2KDM4EMAPT | |
| SCHEMBL170878 | 0.83 | KDM4E (0.69) | ALOX15ACESMN1; SMN2KDM4EMAPT | |
| SCHEMBL2167226 | 0.83 | ALOX15 (0.68) | ALOX15ACESMN1; SMN2KDM4EMAPT | |
| SCHEMBL170877 | 0.83 | KDM4E (0.69) | ALOX15ACESMN1; SMN2KDM4EMAPT | |
| SCHEMBL1755294 | 0.83 | ALOX15 (0.68) | ALOX15ACESMN1; SMN2KDM4EMAPT | |
| SCHEMBL29791658 | 0.83 | LTA4H (0.67) | ALOX15ACESMN1; SMN2KDM4EMAPT | |
| SCHEMBL7297775 | 0.83 | DNMT1 (0.65) | ALOX15ACESMN1; SMN2KDM4EMAPT | |
| SCHEMBL1131418 | 0.82 | ALOX15 (0.67) | ALOX15ACESMN1; SMN2KDM4EMAPT | |
| SCHEMBL991035 | 0.82 | KDM4E (0.68) | ALOX15ACESMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240191212-A1 | Nucleic Acid Molecules Encoding Indoleamine 2,3-Dioxygenase-2 | LANKENAU INST MEDICAL RES (US) | 2024-06-13 | — | — | US | disclosed |
| US-RE49708-E1 | Nucleic acid molecules encoding indoleamine 2,3-dioxygenase-2 | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2023-10-24 | — | — | US | disclosed |
| US-8476454-B2 | IDO inhibitors and methods of use | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2013-07-02 | — | — | US | disclosed |
| US-20100233166-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE | PRENDERGAST GEORGE C | 2010-09-16 | — | — | US | disclosed |
| US-7714139-B2 | IDO inhibitors and methods of use | LANKENAU INSTITUTE FOR MEDCIAL RESEARCH (US) | 2010-05-11 | — | — | US | disclosed |
| EP-1606285-A4 | NOVEL IDO INHIBITORS AND METHODS OF USE | LANKENAU INST MEDICAL RES (US) | 2009-03-18 | — | — | EP | disclosed |
| US-20070173524-A1 | \"Novel ido inhibitors and methods of use | LANKENAU INSTITUTE FOR MEDICAL RESEARCH | 2007-07-26 | — | — | US | disclosed |
| EP-1606285-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE | Lankenau Institute for Medical Research (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004094409-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173524-A1 | \"Novel ido inhibitors and methods of use | IDO1, IDO2, INMT | ALOX15 855/4885ACE 1793/4885SMN1; SMN2 2948/4885 |
| US-20100233166-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE | IDO1, IDO2, INMT | ALOX15 771/4885ACE 2304/4885SMN1; SMN2 3706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.