SCHEMBL170878

SCHEMBL170878

O=C(O)[C@H](Cc1c[nH]c2ccccc12)NO

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.69
MAPT P10636 2/20 0.69
APAF1 O14727 1/20 0.69
POLB P06746 1/20 0.69
RECQL P46063 1/20 0.69
L3MBTL1 Q9Y468 1/20 0.69
ALOX15 P16050 1/20 0.68
ACE P12821 3/20 0.67
SMN1; SMN2 Q16637 1/20 0.67
MEN1 O00255 1/20 0.65
LMNA P02545 1/20 0.65
MPO P05164 1/20 0.65
TSHR P16473 1/20 0.65
BLM P54132 1/20 0.65
PMP22 Q01453 1/20 0.65
KMT2A Q03164 1/20 0.65
HIF1A Q16665 1/20 0.65
ECE1 P42892 5/20 0.65
ITGB2 P05107 3/20 0.64
ICAM1 P05362 3/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL170877 1.00 KDM4E (0.69) KDM4EMAPTAPAF1POLBRECQL
Water SCHEMBL5384989 0.99 KDM4E (0.68) KDM4EMAPTAPAF1POLBRECQL
SCHEMBL991035 0.99 KDM4E (0.68) KDM4EMAPTAPAF1POLBRECQL
Water SCHEMBL5384991 0.99 KDM4E (0.68) KDM4EMAPTAPAF1POLBRECQL
SCHEMBL991039 0.99 KDM4E (0.68) KDM4EMAPTAPAF1POLBRECQL
Glutaral SCHEMBL5081526 0.90 ALOX15 (0.61) KDM4EMAPTAPAF1POLBRECQL
SCHEMBL30782236 0.90 ALOX15 (0.70) KDM4EMAPTAPAF1POLBRECQL
SCHEMBL2167226 0.88 ALOX15 (0.68) KDM4EMAPTAPAF1POLBRECQL
SCHEMBL1755294 0.88 ALOX15 (0.68) KDM4EMAPTAPAF1POLBRECQL
SCHEMBL3873860 0.88 KDM4E (0.61) KDM4EMAPTAPAF1POLBRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1370 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260092179-A1 GENETICALLY MODIFIED HOST CELLS PRODUCING VIOLACEIN, ANALOGUES, AND DERIVATIVES THEREOF OCTARINE BIO APS (DK) 2026-04-02 US claimed
EP-4709360-A1 MULTIPHASE TABLET HAVING SLEEP-PROMOTING EFFECT Maria Clementine Martin Klosterfrau Vertriebsgesellschaft mbH (DE) 2026-03-18 EP claimed
US-20250179018-A1 SYNTHESIS OF (S)-6-HYDROXYTRYPTOPHAN AND DERIVATIVES THEREOF HEIDELBERG PHARMA RESEARCH GMBH (DE) 2025-06-05 US claimed
CN-119842835-A Application of mutation site as target spot in preparation of fluorine-containing hydroxyl tryptophan 天津大学 2025-04-18 CN claimed
WO-2025045432-A1 MULTIPHASE TABLET HAVING SLEEP-PROMOTING EFFECT MARIA CLEMENTINE MARTIN KLOSTERFRAU VERTRIEBSGESELLSCHAFT MBH (DE) 2025-03-06 WO claimed
CN-118979005-B 5-Hydroxytryptophan production strain and construction method and application thereof 天津科技大学 2025-02-18 CN claimed
US-20250041439-A1 ANTIBODY-DRUG CONJUGATES SPIREA LIMITED (GB) 2025-02-06 US claimed
EP-4500182-A1 PROGNOSTIC BIOMARKERS The University of Liverpool (GB) 2025-02-05 EP claimed
EP-3661938-B1 NOVEL METHOD FOR SYNTHESIZING AMANITINS HEIDELBERG PHARMA RES GMBH (DE) 2025-01-15 EP claimed
WO-2024258190-A1 HAIR DYE COMPOSITION FOR PREMATURE GRAY HAIR AND METHOD FOR PREPARING SAME 코스맥스 주식회사 2024-12-19 WO claimed
US-6232336-B1 HYPOTENSIVE AGENTS; NEUROTRANSMISSION; CYTOTOXICITY THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2001-05-15 US claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000068413-A1 HALO- OR HYDROXY-SUBSTITUTED NOCATHIACIN ANTIBIOTICS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-11-16 WO claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-1000023-A2 NOVEL NITRIC OXIDE-RELEASING AMIDINE- AND ENAMINE-DERIVED DIAZENIUMDIOLATES, COMPOSITIONS AND USES THEREOF AND METHOD OF MAKING SAME THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) 2000-05-17 EP claimed
WO-1999059573-A9 STABILIZED PHARMACEUTICAL PREPARATIONS OF GAMMA-AMINOBUTYRIC ACID DERIVATIVES AND PROCESS FOR PREPARING THE SAME WARNER LAMBERT CO (US) 2000-05-04 WO claimed
WO-1999061038-A1 COMPOSITION HAVING THERAPEUTIC AND/OR NUTRITIONALLY ACTIVE SUBSTITUENT ADAMS FOOD LTD. (US) 1999-12-02 WO claimed
WO-1999001427-A2 NOVEL NITRIC OXIDE-RELEASING AMIDINE- AND ENAMINE-DERIVED DIAZENIUMDIOLATES, COMPOSITIONS AND USES THEREOF AND METHOD OF MAKING SAME THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH (US) 1999-01-14 WO claimed
US-5225529-A Central nervous system disorders such as Alzheimer*s disease FARMHISPANIA S.A. (ES) 1993-07-06 US claimed
EP-0381070-A1 Synthetic amphiphilic glycoconjugates for neurological use FARMHISPANIA S.A. (ES) 1990-08-08 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092179-A1 GENETICALLY MODIFIED HOST CELLS PRODUCING VIOLACEIN, ANALOGUES, AND DERIVATIVES THEREOF TDO2, BLVRB, INMT KDM4E 1143/4885MAPT 1741/4885APAF1 2125/4885
US-20250179018-A1 SYNTHESIS OF (S)-6-HYDROXYTRYPTOPHAN AND DERIVATIVES THEREOF AANAT, HNMT, HTR6 KDM4E 3298/4885MAPT 1033/4885APAF1 3674/4885
US-20250041439-A1 ANTIBODY-DRUG CONJUGATES CD44, CD47, FCGR3B KDM4E 1199/4885MAPT 79/4885APAF1 4072/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.