Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PPIB | P23284 | 1/20 | 0.39 |
| ▸ | PPIA | P62937 | 1/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
| ▸ | PPIG | Q13427 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407932 | 0.88 | HTT (0.47) | HTTLMNAMAPTTDP1KDM4E | |
| SCHEMBL3404972 | 0.83 | MGLL (0.51) | HTTCYP3A4MAPTGAASMN1; SMN2 | |
| SCHEMBL3401395 | 0.74 | MAPT (0.40) | HTTMAPTTDP1KDM4EGLA | |
| SCHEMBL9195477 | 0.70 | LMNA (0.56) | HTTLMNACYP1A2CYP3A4MAOA | |
| SCHEMBL29023046 | 0.70 | LMNA (0.49) | HTTLMNACYP1A2CYP3A4MAOA | |
| SCHEMBL2493638 | 0.70 | MEN1 (0.51) | HTTLMNACYP1A2CYP3A4MAOA | |
| SCHEMBL3813706 | 0.69 | MAPT (0.51) | HTTLMNAMAPTTDP1KDM4E | |
| SCHEMBL13724309 | 0.69 | KMT2A (0.52) | MAPTTDP1KDM4EGLAGAA | |
| Hydrochloric Acid SCHEMBL27454826 | 0.68 | LMNA (0.50) | HTTLMNACYP1A2CYP3A4MAOA | |
| SCHEMBL9714370 | 0.68 | CYP3A4 (0.55) | HTTLMNACYP1A2CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252604-A1 | THIAZOLE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR | R-Tech Ueno, Ltd. (JP) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009096609-A1 | THIAZOLE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR | R-TECH UENO, LTD. (JP) | 2009-08-06 | — | — | WO | disclosed |