Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28025686 | 0.78 | ELANE (0.47) | ELANEKDM4EALDH1A1HPGDGAA | |
| SCHEMBL12990293 | 0.75 | CYP1A2 (0.40) | ELANEKDM4EALDH1A1HPGDGAA | |
| SCHEMBL29726892 | 0.71 | BACE1 (0.44) | ELANEKDM4EALDH1A1HPGDGAA | |
| SCHEMBL1257332 | 0.71 | BACE1 (0.44) | ELANEKDM4EALDH1A1HPGDGAA | |
| SCHEMBL15919425 | 0.70 | ACACA (0.48) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL3397178 | 0.69 | LOXL2 (0.58) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL8511566 | 0.68 | MAOA (0.50) | KDM4EALDH1A1HPGDGAAKMT2A | |
| SCHEMBL28807199 | 0.68 | MYC (0.48) | KDM4EALDH1A1HPGDGAAKMT2A | |
| SCHEMBL362901 | 0.68 | CYP1A2 (0.64) | KDM4EALDH1A1HPGDGAAKMT2A | |
| SCHEMBL1845788 | 0.68 | NCF1 (0.60) | KDM4EALDH1A1HPGDGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247584-A1 | FUSED PYRIDINES ACTIVE AS INHIBITORS OF C-MET | F. Hoffmann-La Roche AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009093049-A1 | FUSED PYRIDINES ACTIVE AS INHIBITORS OF C-MET | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-30 | — | — | WO | disclosed |