Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.50 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 2/20 | 0.62 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6276133 | 0.98 | LTA4H (0.64) | LTA4HNR5A1TP53TSHRPLA2G4B | |
| SCHEMBL838064 | 0.98 | LTA4H (0.64) | LTA4HNR5A1TP53TSHRPLA2G4B | |
| SCHEMBL3874556 | 0.98 | LTA4H (0.64) | LTA4HNR5A1TP53TSHRPLA2G4B | |
| SCHEMBL12748728 | 0.98 | LTA4H (0.64) | LTA4HNR5A1TP53TSHRPLA2G4B | |
| SCHEMBL2224932 | 0.98 | LTA4H (0.64) | LTA4HNR5A1TP53TSHRPLA2G4B | |
| SCHEMBL145006 | 0.98 | LTA4H (0.64) | LTA4HNR5A1TP53TSHRPLA2G4B | |
| SCHEMBL4839363 | 0.98 | LTA4H (0.64) | LTA4HNR5A1TP53TSHRPLA2G4B | |
| SCHEMBL3200931 | 0.93 | LTA4H (0.63) | LTA4HNR5A1TP53TSHRPLA2G4B | |
| SCHEMBL4619982 | 0.92 | LTA4H (0.57) | LTA4HNR5A1TP53TSHRPLA2G4B | |
| SCHEMBL2006889 | 0.92 | LTA4H (0.57) | LTA4HNR5A1TP53TSHRPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1249221-B1 | DENTAL ADHESIVE COMPOSITION | TOKUYAMA DENTAL CORP (JP) | 2010-10-13 | — | — | EP | disclosed |
| US-7601480-B2 | Photoactive compounds | AZ ELECTRONIC MATERIALS USA CORP. (US) | 2009-10-13 | — | — | US | disclosed |
| EP-2102184-A2 | PHOTOACTIVE COMPOUNDS | AZ Electronic Materials USA Corp. (US) | 2009-09-23 | — | — | EP | disclosed |
| US-20080153032-A1 | Photoactive Compounds | MERCK PATENT GMBH (DE) | 2008-06-26 | — | — | US | disclosed |
| US-7390613-B1 | Photoactive compounds | AZ ELECTRONIC MATERIALS USA CORP. (US) | 2008-06-24 | — | — | US | disclosed |
| WO-2008068617-A2 | PHOTOACTIVE COMPOUNDS | AZ ELECTRONIC MATERIALS USA CORP. (DE) | 2008-06-12 | — | — | WO | disclosed |
| US-20080131810-A1 | Photoactive Compounds | MERCK PATENT GMBH (DE) | 2008-06-05 | — | — | US | disclosed |
| US-6759449-B2 | NONCROSSLINKING POLYMETHYL METHACRYLATE AND POLYETHYL METH-ACRYLATE SPHERICAL FILLER, UNSATURATED ACID FUNCTIONALIZED MONOMER AND POLYMERIZATION INITIATOR | TOKUYAMA DENTAL CORPORATION (JP) | 2004-07-06 | — | — | US | disclosed |
| US-20030050359-A1 | Dental adhesive composition | TOKUYAMA DENTAL CORPORATION (JP) | 2003-03-13 | — | — | US | disclosed |
| EP-1249221-A1 | DENTAL ADHESIVE COMPOSITION | Tokuyama Dental Corporation (JP) | 2002-10-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080131810-A1 | Photoactive Compounds | CRY2, AOC2, AFF2 | CHRM2 2323/4885CHRM1 2608/4885CHRM3 2109/4885 |
| US-20080153032-A1 | Photoactive Compounds | SUN2, CRY2, SCO2 | CHRM2 2335/4885CHRM1 2535/4885CHRM3 1827/4885 |
| US-20030050359-A1 | Dental adhesive composition | CAD, ASIC1, CD44 | CHRM2 3358/4885CHRM1 1758/4885CHRM3 3259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.