Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 5/20 | 0.36 |
| ▸ | EHMT1 | Q9H9B1 | 5/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406068 | 0.90 | NPC1 (0.46) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3410260 | 0.88 | NPC1 (0.53) | NPC1RAB9AMEN1KMT2AKCNH2 | |
| SCHEMBL3410316 | 0.86 | IMPDH2 (0.44) | NPC1RAB9APOLBKCNH2DOT1L | |
| SCHEMBL3410702 | 0.85 | USP2 (0.45) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3406681 | 0.84 | NPC1 (0.41) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL3407955 | 0.83 | NPC1 (0.51) | NPC1RAB9AMEN1KMT2AKCNH2 | |
| SCHEMBL3406662 | 0.83 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2KCNH2DOT1L | |
| SCHEMBL3406232 | 0.82 | NPC1 (0.41) | NPC1RAB9AKCNH2DOT1LIMPDH2 | |
| SCHEMBL3406468 | 0.82 | KCNH2 (0.42) | NPC1RAB9ACYP1A2POLBCYP2C9 | |
| SCHEMBL3408568 | 0.82 | NPC1 (0.39) | NPC1RAB9AKCNH2DOT1LIMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |