Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 10/20 | 0.43 |
| ▸ | CA2 | P00918 | 10/20 | 0.43 |
| ▸ | CA6 | P23280 | 9/20 | 0.43 |
| ▸ | CA7 | P43166 | 9/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 9/20 | 0.43 |
| ▸ | CA12 | O43570 | 8/20 | 0.43 |
| ▸ | CA4 | P22748 | 8/20 | 0.43 |
| ▸ | CA9 | Q16790 | 8/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 8/20 | 0.43 |
| ▸ | CA3 | P07451 | 7/20 | 0.43 |
| ▸ | CA5A | P35218 | 5/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 7/20 | 0.39 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2925439 | 0.84 | TRPV4 (0.47) | SLC6A2SLC6A4SLC6A3LMNAWDR5 | |
| SCHEMBL6951702 | 0.76 | CYP2C8 (0.41) | SLC6A2SLC6A4SLC6A3LMNAL3MBTL1 | |
| SCHEMBL962913 | 0.72 | CA1 (0.53) | CA1CA2CA6CA7CA5B | |
| SCHEMBL29587590 | 0.72 | CA1 (0.53) | CA1CA2CA6CA7CA5B | |
| SCHEMBL7952462 | 0.72 | PTGS2 (0.51) | CA1CA2CA6CA7CA5B | |
| SCHEMBL939487 | 0.72 | MMP2 (0.62) | CA1CA2CA6CA7CA5B | |
| SCHEMBL9870878 | 0.72 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2954709 | 0.71 | WDR5 (0.40) | LMNAWDR5 | |
| SCHEMBL24313730 | 0.71 | CA12 (0.54) | CA1CA2CA12CA4CA9 | |
| SCHEMBL29587540 | 0.71 | CA12 (0.54) | CA1CA2CA12CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231595-B1 | PHENYL ACETIC ACID DERIVATIVES AS INFLAMMATION MODULATORS | AMGEN INC (US) | 2014-04-23 | — | — | EP | disclosed |
| US-8183293-B2 | Phenyl acetic acid derivatives | AMGEN INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183293-B2 | Phenyl acetic acid derivatives | AMGEN INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183293-B2 | Phenyl acetic acid derivatives | AMGEN INC. (US) | 2012-05-22 | — | — | US | disclosed |
| EP-2231595-A1 | PHENYL ACETIC ACID DERIVATIVES AS INFLAMMATION MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | disclosed |
| US-20090275659-A1 | Phenyl acetic acid derivatives as inflammation modulators | AMGEN INC. (US) | 2009-11-05 | — | — | US | disclosed |
| US-20090275659-A1 | Phenyl acetic acid derivatives as inflammation modulators | AMGEN INC. (US) | 2009-11-05 | — | — | US | disclosed |
| US-20090275659-A1 | Phenyl acetic acid derivatives as inflammation modulators | AMGEN INC. (US) | 2009-11-05 | — | — | US | disclosed |
| WO-2009085177-A1 | PHENYL ACETIC ACID DERIVATIVES AS INFLAMMATION MODULATORS | AMGEN INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009085177-A1 | PHENYL ACETIC ACID DERIVATIVES AS INFLAMMATION MODULATORS | AMGEN INC. (US) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275659-A1 | Phenyl acetic acid derivatives as inflammation modulators | NFKBIA, HCAR2, NFATC1 | CA1 1730/4885CA2 1159/4885CA6 747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.