Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3413639 | 0.89 | MEN1 (0.47) | BRD4KMT2AMEN1MAPTNPC1 | |
| SCHEMBL3407740 | 0.88 | NPC1 (0.49) | KMT2AMEN1PARP14MAPTNPC1 | |
| SCHEMBL3409988 | 0.83 | MAPT (0.53) | KMT2AMEN1MAPTNPC1PKM | |
| SCHEMBL3411281 | 0.78 | EGFR (0.52) | BRD4KMT2AMEN1NPC1RAB9A | |
| SCHEMBL3405825 | 0.76 | MAPT (0.55) | KMT2AMEN1MAPTPARP1NPC1 | |
| SCHEMBL3408234 | 0.76 | KDM4E (0.54) | KMT2AMEN1CA12CA9MAPT | |
| SCHEMBL3410873 | 0.75 | ALDH1A1 (0.41) | KMT2AMEN1MAPTPKMSMN1; SMN2 | |
| SCHEMBL3411555 | 0.72 | ALDH1A1 (0.46) | KMT2AMEN1MAPTNPC1RAB9A | |
| SCHEMBL2637556 | 0.72 | POLB (0.46) | KMT2AMEN1MAPTNPC1RAB9A | |
| SCHEMBL3405698 | 0.71 | ALDH1A1 (0.47) | KMT2AMEN1CA12CA9PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | claimed |
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | disclosed |