Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.43 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.43 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.43 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407406 | 0.89 | BRD4 (0.46) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL3407740 | 0.80 | NPC1 (0.49) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL3409988 | 0.78 | MAPT (0.53) | MEN1KMT2ANPC1KDM4EGAA | |
| SCHEMBL2637478 | 0.74 | HSP90AA1 (0.47) | MEN1KMT2ANPC1RAB9AKCNK3 | |
| SCHEMBL3411281 | 0.70 | EGFR (0.52) | MEN1KMT2ANPC1RAB9ABRD4 | |
| SCHEMBL2637556 | 0.70 | POLB (0.46) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL16111189 | 0.69 | POLB (0.55) | MEN1KMT2AKDM4EGAAMAPT | |
| SCHEMBL3408234 | 0.68 | KDM4E (0.54) | MEN1KMT2AKDM4EGAAMAPT | |
| SCHEMBL3411555 | 0.68 | ALDH1A1 (0.46) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL3410873 | 0.67 | ALDH1A1 (0.41) | MEN1KMT2AKDM4EMAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | claimed |
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | disclosed |