Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408234 | 0.84 | KDM4E (0.54) | KMT2AADORA3MEN1MAPK10ALDH1A1 | |
| SCHEMBL3407406 | 0.78 | BRD4 (0.46) | KMT2AADORA3NPC1MEN1RAB9A | |
| SCHEMBL3410031 | 0.76 | MAPT (0.52) | KMT2ANPC1MEN1RAB9ASLC22A12 | |
| SCHEMBL3407318 | 0.74 | ALDH1A1 (0.53) | KMT2AADORA3NPC1MEN1RAB9A | |
| SCHEMBL2638043 | 0.74 | MAPK10 (0.45) | KMT2AADORA3NPC1MEN1RAB9A | |
| SCHEMBL2069110 | 0.73 | KMT2A (0.78) | EGFRKMT2ANPC1MEN1RAB9A | |
| SCHEMBL2637246 | 0.72 | MAPK10 (0.41) | EGFRKMT2AMEN1RAB9ASLC22A12 | |
| SCHEMBL2637269 | 0.71 | SLC22A12 (0.41) | EGFRKMT2ANPC1MEN1RAB9A | |
| SCHEMBL2637462 | 0.71 | SLC22A12 (0.41) | EGFRSRCKMT2ANPC1MEN1 | |
| SCHEMBL3409988 | 0.71 | MAPT (0.53) | SRCKMT2ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | claimed |
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | disclosed |