Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407406 | 0.88 | BRD4 (0.46) | NPC1RAB9AMAPTPARP14SMN1; SMN2 | |
| SCHEMBL3413639 | 0.80 | MEN1 (0.47) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL3409988 | 0.77 | MAPT (0.53) | NPC1MAPTLMNASMN1; SMN2KMT2A | |
| SCHEMBL6257175 | 0.74 | KMT2A (0.69) | NPC1RAB9AMAPTLMNAPARP14 | |
| SCHEMBL11399112 | 0.73 | UBE2N (0.60) | NPC1RAB9AMAPTLMNAPARP14 | |
| SCHEMBL6259345 | 0.72 | KDR (0.61) | NPC1RAB9AMAPTLMNAPARP14 | |
| SCHEMBL9728959 | 0.71 | RAB9A (0.72) | NPC1RAB9AMAPTLMNAPARP14 | |
| SCHEMBL6257352 | 0.70 | MAPT (0.82) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3411281 | 0.69 | EGFR (0.52) | NPC1RAB9AKMT2AMEN1ADORA3 | |
| SCHEMBL148105 | 0.69 | RAB9A (0.62) | NPC1RAB9AMAPTPARP14SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | claimed |
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | disclosed |