Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | LOX | P28300 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11875429 | 0.91 | CA1 (0.47) | ALDH1A1LMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL18381561 | 0.81 | LMNA (0.47) | ALDH1A1LMNAHTTSMN1; SMN2NPC1 | |
| SCHEMBL4482607 | 0.81 | LMNA (0.60) | ALDH1A1LMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL21646275 | 0.80 | SMN1; SMN2 (0.50) | ALDH1A1LMNAHTTSMN1; SMN2NPC1 | |
| SCHEMBL3056367 | 0.79 | ALDH1A1 (0.53) | ALDH1A1LMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL15699683 | 0.79 | ALDH1A1 (0.53) | ALDH1A1LMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL3069358 | 0.79 | LMNA (0.53) | ALDH1A1LMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL2248882 | 0.79 | CA1 (0.55) | ALDH1A1LMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL1146125 | 0.79 | PSIP1 (0.59) | ALDH1A1LMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL11539408 | 0.78 | LMNA (0.55) | ALDH1A1LMNAHTTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022263829-A1 | COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY | Z Factor Limited (GB) | 2022-12-22 | — | — | WO | disclosed |
| US-11332459-B2 | Benzimidazole derivatives and their uses | TEIJIN PHARMA LIMITED (JP) | 2022-05-17 | — | — | US | disclosed |
| US-20200308145-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USES | AMGEN INC. (US) | 2020-10-01 | — | — | US | disclosed |
| EP-2257340-A2 | COMPOUNDS FOR TREATING MUSCULAR DYSTROPHY | BioMarin IGA Limited (BS) | 2010-12-08 | — | — | EP | disclosed |
| US-20100305120-A1 | COMPOUNDS FOR TREATING MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED | 2010-12-02 | — | — | US | disclosed |
| US-7629363-B2 | antiinflammatory agent for treating asthma and chronic pulmonary inflammatory disease | PFIZER INC (US) | 2009-12-08 | — | — | US | disclosed |
| EP-1490064-B1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORP (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2009121623-A2 | COMPOUNDS FOR TREATING MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2009-10-08 | — | — | WO | disclosed |
| US-7067540-B2 | Substituted pyridinones | PHARMACIA CORPORATION (US) | 2006-06-27 | — | — | US | disclosed |
| US-20050176775-A1 | Substituted pyridinones | PHARMACIA CORPORATION | 2005-08-11 | — | — | US | disclosed |
| US-4906654-A | Cyclohept[b]indoleakanoic acids, pharmaceutical compositions and use | MERCK FROSST CANADA, INC. (CA) | 1990-03-06 | — | — | US | disclosed |
| EP-0310179-A2 | Tetrahydrocarbazole esters | MERCK FROSST CANADA INC. (CA) | 1989-04-05 | — | — | EP | disclosed |
| EP-0307077-A1 | Tetrahydrocarbazoles for the improvement of cyclosporin therapy | MERCK FROSST CANADA INC. (CA) | 1989-03-15 | — | — | EP | disclosed |
| US-4808608-A | ANTIALLERGENS, HYPOTENSIVE AGENT, ANTICOAGULANT | MERCK & CO., INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0300676-A2 | Tetrahydrocarbazole 1-alkanoic acids | MERCK FROSST CANADA INC. (CA) | 1989-01-25 | — | — | EP | disclosed |
| EP-0178775-B1 | FLUORESCENT INDICATOR DYES FOR CALCIUM IONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1988-11-09 | — | — | EP | disclosed |
| US-4775680-A | PROSTAGLANDIN ANTAGONISTS | MERCK & CO., INC. (US) | 1988-10-04 | — | — | US | disclosed |
| US-4603209-A | STILBENE-TYPE FLUOROPHORE, TWO AMINODIACETIC ACID MOIETIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1986-07-29 | — | — | US | disclosed |
| EP-0178775-A2 | Fluorescent indicator dyes for calcium ions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1986-04-23 | — | — | EP | disclosed |
| US-3933836-A | Pyridinylidene guanidines | E. R. SQUIBB & SONS, INC. (US) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305120-A1 | COMPOUNDS FOR TREATING MUSCULAR DYSTROPHY | CPT1B, SMN1; SMN2, GYS1 | ALDH1A1 359/4885LMNA 192/4885HTT 1560/4885 |
| US-20200308145-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USES | TRPC6, TRPV6, TRPM6 | ALDH1A1 1564/4885LMNA 4022/4885HTT 2535/4885 |
| US-20050176775-A1 | Substituted pyridinones | MAPK1, MAPK6, MAP3K6 | ALDH1A1 741/4885LMNA 1884/4885HTT 4506/4885 |
| US-11332459-B2 | Benzimidazole derivatives and their uses | TRPC6, TRPV6, TRPM6 | ALDH1A1 1564/4885LMNA 4022/4885HTT 2535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.