Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA1 | Q09470 | 4/20 | 0.51 |
| ▸ | KCNAB1 | Q14722 | 4/20 | 0.51 |
| ▸ | TMPRSS2 | O15393 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1189521 | 0.86 | ESR2 (0.55) | KCNA1KCNAB1TMPRSS2NPC1RAB9A | |
| SCHEMBL3405294 | 0.81 | RAB9A (0.63) | KCNA1KCNAB1TMPRSS2NPC1RAB9A | |
| SCHEMBL1188468 | 0.80 | KCNA1 (0.40) | KCNA1KCNAB1TMPRSS2NPC1RAB9A | |
| SCHEMBL1188471 | 0.80 | KCNA1 (0.40) | KCNA1KCNAB1TMPRSS2NPC1RAB9A | |
| SCHEMBL1188451 | 0.78 | KCNA1 (0.40) | KCNA1KCNAB1TMPRSS2NPC1RAB9A | |
| SCHEMBL1188453 | 0.78 | KCNA1 (0.40) | KCNA1KCNAB1TMPRSS2NPC1RAB9A | |
| SCHEMBL5452223 | 0.77 | TMPRSS2 (0.55) | KCNA1KCNAB1TMPRSS2NPC1RAB9A | |
| SCHEMBL11903038 | 0.77 | TMPRSS2 (0.50) | KCNA1KCNAB1TMPRSS2NPC1RAB9A | |
| SCHEMBL5460595 | 0.77 | CASP3 (0.70) | KCNA1KCNAB1TMPRSS2NPC1RAB9A | |
| SCHEMBL3402909 | 0.76 | NPC1 (0.67) | KCNA1KCNAB1TMPRSS2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256105-B1 | NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2013-12-04 | — | — | EP | disclosed |
| EP-2256105-A1 | NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2010-12-01 | — | — | EP | disclosed |