Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138863 | 0.86 | HPGD (0.77) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL21993 | 0.79 | HPGD (1.00) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4147334 | 0.77 | GPR27 (0.72) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL14112955 | 0.77 | HPGD (0.69) | HPGDALDH1A1MEN1KMT2ALMNA | |
| Iodomethane SCHEMBL20530190 | 0.76 | HPGD (0.93) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL29177155 | 0.76 | HPGD (0.68) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL437231 | 0.76 | ALDH1A1 (0.87) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL18190481 | 0.76 | MEN1 (0.72) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL7757783 | 0.75 | HDAC6 (0.44) | KDM4ELMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL2169634 | 0.75 | MEN1 (0.68) | HPGDALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197850-A1 | DERIVATIVES OF N-PHENYLACETAMIDE, INHIBITORS OF THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Galderma Research & Development (FR) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009030747-A1 | DERIVATIVES OF N-PHENYLACETAMIDE, INHIBITORS OF THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-03-12 | — | — | WO | disclosed |