Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6671895 | 0.81 | NPC1 (0.51) | HDAC6HDAC1HDAC7GAAKDM4E | |
| SCHEMBL11396221 | 0.81 | HTT (0.36) | HDAC6HDAC1MPOSMN1; SMN2HIF1A | |
| Methane SCHEMBL28422886 | 0.77 | CYP1A2 (0.46) | KDM4EMPOHIF1ALMNAALOX15 | |
| SCHEMBL14514161 | 0.77 | TDP1 (0.37) | KDM4EMPOHIF1ALMNANCEH1 | |
| SCHEMBL8732527 | 0.77 | TDP2 (0.36) | GAAMPOSMN1; SMN2HIF1ALMNA | |
| SCHEMBL28010662 | 0.75 | ACHE (0.33) | KDM4ESMN1; SMN2LMNANCEH1HSD17B10 | |
| SCHEMBL3411986 | 0.75 | HPGD (0.66) | KDM4ESMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL6707559 | 0.75 | ALDH1A1 (0.39) | GAAKDM4ESMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL27404315 | 0.75 | POLB (0.53) | GAAKDM4ESMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL7177477 | 0.75 | SMN1; SMN2 (0.39) | GAAKDM4ESMN1; SMN2LMNAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077938-A1 | 2-(2-METHYLPHENYL)-3,4-DIHYDRO-2H-PYRROL DERIVATIVES | BAYER AG (DE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059967-A1 | 2-(2-METHYLPHENYL)-3,4-DIHYDRO-2H-PYRROL DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-11-25 | — | — | WO | disclosed |