Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethane SCHEMBL28051940 | 0.98 | ALDH1A1 (0.37) | ALDH1A1HPGDHTTSMN1; SMN2ERN1 | |
| SCHEMBL16096641 | 0.87 | ALDH1A1 (0.38) | ALDH1A1HPGDHTTSMN1; SMN2ERN1 | |
| SCHEMBL15570938 | 0.83 | CA12 (0.49) | ALDH1A1HPGDHTTSMN1; SMN2CA12 | |
| SCHEMBL29935810 | 0.80 | ERN1 (0.49) | ALDH1A1ERN1MAPTCA12CA1 | |
| SCHEMBL1052852 | 0.80 | ERN1 (0.49) | ALDH1A1ERN1MAPTCA12CA1 | |
| SCHEMBL3417565 | 0.80 | HPGD (0.38) | ALDH1A1HPGDHTTSMN1; SMN2MAPT | |
| SCHEMBL3417563 | 0.80 | HPGD (0.38) | ALDH1A1HPGDHTTSMN1; SMN2MAPT | |
| SCHEMBL4857523 | 0.79 | ALDH1A1 (0.36) | ALDH1A1HPGDHTTSMN1; SMN2ERN1 | |
| SCHEMBL28267778 | 0.79 | KDM1A (0.39) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL26124770 | 0.78 | EGFR (0.36) | ALDH1A1HPGDHTTSMN1; SMN2ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10294212-B2 | Inhibitors of the kynurenine pathway | CURADEV PHARMA, PVT. LTD. (IN) | 2019-05-21 | — | — | US | disclosed |
| US-10294212-B2 | Inhibitors of the kynurenine pathway | CURADEV PHARMA, PVT. LTD. (IN) | 2019-05-21 | — | — | US | disclosed |
| CN-105209449-B | Inhibitors of the kynurenine pathway | 库拉德夫制药私人有限公司 | 2019-02-01 | — | — | CN | disclosed |
| EP-2970173-B1 | INHIBITORS OF THE KYNURENINE PATHWAY | CURADEV PHARMA PRIVATE LTD (IN) | 2018-05-09 | — | — | EP | disclosed |
| EP-2970173-B1 | INHIBITORS OF THE KYNURENINE PATHWAY | CURADEV PHARMA PRIVATE LTD (IN) | 2018-05-09 | — | — | EP | disclosed |
| US-20180030026-A1 | INHIBITORS OF THE KYNURENINE PATHWAY | CURADEV PHARMA PVT LTD | 2018-02-01 | — | — | US | disclosed |
| US-20180030026-A1 | INHIBITORS OF THE KYNURENINE PATHWAY | CURADEV PHARMA PVT LTD | 2018-02-01 | — | — | US | disclosed |
| US-20180030026-A1 | INHIBITORS OF THE KYNURENINE PATHWAY | CURADEV PHARMA PVT LTD | 2018-02-01 | — | — | US | disclosed |
| US-9815811-B2 | Inhibitors of the kynurenine pathway | CURADEV PHARMA, PVT. LTD. (IN) | 2017-11-14 | — | — | US | disclosed |
| US-9815811-B2 | Inhibitors of the kynurenine pathway | CURADEV PHARMA, PVT. LTD. (IN) | 2017-11-14 | — | — | US | disclosed |
| WO-2014186035-A1 | INHIBITORS OF THE KYNURENINE PATHWAY | CURADEV PHARMA PRIVATE LTD. (IN) | 2014-11-20 | — | — | WO | disclosed |
| WO-2014186035-A1 | INHIBITORS OF THE KYNURENINE PATHWAY | CURADEV PHARMA PRIVATE LTD. (IN) | 2014-11-20 | — | — | WO | disclosed |
| EP-1554286-B1 | FUSED HETEROCYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-27 | — | — | EP | disclosed |
| CN-100522972-C | Fused heterocyclic isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA NV (BE) | 2009-08-05 | — | — | CN | disclosed |
| US-7501418-B2 | e.g. 3-[4-(2-Methyl-3-phenyl-allyl)-piperazin-1-ylmethyl]-3a,4-dihydro-3H-2,5-dioxa-1,7-diaza-dicyclopenta[a,g]naphthalene; serotonine (5-HT) reuptake inhibitor, alpha 2-adrenoceptor antagonist; antidepressant, anxiolytic agent; Parkinson's disease, eating disorders, psychosis, obesity | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-03-10 | — | — | US | disclosed |
| WO-2008063625-A2 | PYRIDINE COMPOUNDS AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |
| US-20060116378-A1 | Fused heterocyclic isoxazoline derivatives and their use as anti-derpressants | JANSSEN-CILAG S.A. (ES) | 2006-06-01 | — | — | US | disclosed |
| CN-1675224-A | fused heterocyclic isoxazoline derivatives and their use as antidepressants | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-28 | — | — | CN | disclosed |
| EP-1554286-A1 | FUSED HETEROCYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004018483-A1 | FUSED HETEROCYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10294212-B2 | Inhibitors of the kynurenine pathway | IDO1, IDO2, KYNU | ALDH1A1 909/4885HPGD 72/4885HTT 2003/4885 |
| US-20180030026-A1 | INHIBITORS OF THE KYNURENINE PATHWAY | IDO1, IDO2, KYNU | ALDH1A1 909/4885HPGD 72/4885HTT 2003/4885 |
| US-20060116378-A1 | Fused heterocyclic isoxazoline derivatives and their use as anti-derpressants | PARK7, HTR7, TPH2 | ALDH1A1 991/4885HPGD 367/4885HTT 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.