Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417565 | 1.00 | HPGD (0.38) | HPGDTSHRMAPK1HSD17B10LMNA | |
| SCHEMBL3416435 | 0.80 | ALDH1A1 (0.38) | HPGDTSHRLMNAHTTMAPT | |
| Ethane SCHEMBL28051940 | 0.78 | ALDH1A1 (0.37) | HPGDLMNAHTTMAPTALDH1A1 | |
| SCHEMBL2161122 | 0.72 | LMNA (0.41) | HPGDHSD17B10LMNAHTTCCNT1 | |
| SCHEMBL15596168 | 0.72 | CHRNB2 (0.47) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL15858729 | 0.72 | CHRNB4 (0.50) | HPGDMAPTALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL6136966 | 0.72 | CCNC (0.52) | HPGDALDH1A1NPC1CYP1A2CYP3A4 | |
| SCHEMBL6136963 | 0.72 | CCNC (0.52) | HPGDALDH1A1NPC1CYP1A2CYP3A4 | |
| SCHEMBL31139331 | 0.71 | CYP11B1 (0.41) | TSHRHSD17B10LMNAHASPINMAPT | |
| SCHEMBL764171 | 0.70 | CHRNB4 (0.33) | CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554286-B1 | FUSED HETEROCYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-27 | — | — | EP | disclosed |
| US-7501418-B2 | e.g. 3-[4-(2-Methyl-3-phenyl-allyl)-piperazin-1-ylmethyl]-3a,4-dihydro-3H-2,5-dioxa-1,7-diaza-dicyclopenta[a,g]naphthalene; serotonine (5-HT) reuptake inhibitor, alpha 2-adrenoceptor antagonist; antidepressant, anxiolytic agent; Parkinson's disease, eating disorders, psychosis, obesity | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-03-10 | — | — | US | disclosed |
| US-20060116378-A1 | Fused heterocyclic isoxazoline derivatives and their use as anti-derpressants | JANSSEN-CILAG S.A. (ES) | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116378-A1 | Fused heterocyclic isoxazoline derivatives and their use as anti-derpressants | PARK7, HTR7, TPH2 | HPGD 367/4885TSHR 437/4885MAPK1 3227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.