Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9222791 | 0.79 | ALDH1A1 (0.71) | ALDH1A1PKMKDM4EGAAHSD17B10 | |
| SCHEMBL8978544 | 0.78 | ALDH1A1 (1.00) | ALDH1A1PKMKDM4EGAAHSD17B10 | |
| SCHEMBL8978582 | 0.75 | ALDH1A1 (0.71) | ALDH1A1PKMKDM4EGAAHSD17B10 | |
| SCHEMBL13984004 | 0.75 | ALDH1A1 (0.57) | ALDH1A1PKMKDM4EGAAHSD17B10 | |
| SCHEMBL29728077 | 0.75 | ALDH1A1 (0.71) | ALDH1A1PKMKDM4EGAAHSD17B10 | |
| SCHEMBL8978571 | 0.73 | ALDH1A1 (0.67) | ALDH1A1PKMKDM4EGAAHSD17B10 | |
| SCHEMBL1545303 | 0.71 | TDP1 (0.67) | ALDH1A1KDM4EHSD17B10LMNAAPOBEC3G | |
| SCHEMBL919250 | 0.70 | HSD17B10 (0.73) | ALDH1A1PKMKDM4EGAAHSD17B10 | |
| SCHEMBL3421959 | 0.70 | MKNK1 (0.52) | KDM4EGAALMNATSHRTDP1 | |
| SCHEMBL31469002 | 0.70 | MKNK1 (0.52) | KDM4EGAALMNATSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007747-B1 | PROCESS FOR PREPARING HETEROCYCLIC DERIVATIVES | GLAXO GROUP LTD (GB) | 2013-11-20 | — | — | EP | disclosed |
| US-7838680-B2 | Process for preparing heterocyclic derivatives | GLAXO GROUP LIMITED (GB) | 2010-11-23 | — | — | US | disclosed |
| US-20100048895-A1 | Process for Preparing Heterocyclic Derivatives | GLAXO GROUP LIMITED (GB) | 2010-02-25 | — | — | US | disclosed |
| US-20080269195-A1 | Compounds Having Affinity For the Dopamine D3 Receptor and Uses Thereof in Medicine | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | US | disclosed |
| US-20070232808-A1 | PROCESS FOR PREPARING HETEROCYCLIC DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-10-04 | — | — | US | disclosed |
| EP-1773844-A1 | COMPOUNDS HAVING AFFINITY FOR THE DOPAMINE D3 RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006002928-A1 | COMPOUNDS HAVING AFFINITY FOR THE DOPAMINE D3 RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048895-A1 | Process for Preparing Heterocyclic Derivatives | HCAR3, CBR3, HRH4 | ALDH1A1 2942/4885PKM 4445/4885KDM4E 4425/4885 |
| US-20070232808-A1 | PROCESS FOR PREPARING HETEROCYCLIC DERIVATIVES | HCAR3, CBR3, NR4A3 | ALDH1A1 2955/4885PKM 4546/4885KDM4E 4646/4885 |
| US-20080269195-A1 | Compounds Having Affinity For the Dopamine D3 Receptor and Uses Thereof in Medicine | DRD3, SLC6A3, DRD2 | ALDH1A1 1007/4885PKM 2138/4885KDM4E 3815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.