Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL820880 | 0.86 | — | — | |
| SCHEMBL31655454 | 0.84 | TSHR (0.57) | ALDH1A1TSHRSLC6A2SLC6A3LMNA | |
| Acetic Acid SCHEMBL7053200 | 0.83 | ALDH1A1 (0.61) | ALDH1A1HCAR2TSHRSLC6A2SLC6A3 | |
| Formic Acid SCHEMBL10886946 | 0.78 | ALDH1A1 (0.85) | ALDH1A1HCAR2SLC6A2SLC6A3LMNA | |
| Formic Acid SCHEMBL29283293 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HCAR2TSHRSLC6A2SLC6A3 | |
| (Chloromethyl)Benzene SCHEMBL3815600 | 0.75 | ADH1B (0.43) | ALDH1A1TSHRSLC6A2SLC6A3LMNA | |
| Pyridine SCHEMBL9740364 | 0.74 | TSHR (0.46) | ALDH1A1TSHRSLC6A2SLC6A3LMNA | |
| Formic Acid SCHEMBL28229876 | 0.74 | FFAR1 (0.56) | ALDH1A1SLC6A3HDAC6MAOBMAOA | |
| Diphenylmethane SCHEMBL28093285 | 0.74 | CALM1 (0.67) | ALDH1A1TSHRLMNAHDAC6MAOB | |
| E1501 SCHEMBL8586260 | 0.74 | ALDH1A1 (0.85) | ALDH1A1HCAR2TSHRSLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662977-B2 | PI-3 kinase inhibitor prodrugs | SEMAFORE PHARMACEUTICALS, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-20080188423-A1 | PI-3 KINASE INHIBITOR PRODRUGS | SIGNALRX PHARMACEUTICALS, INC. | 2008-08-07 | — | — | US | disclosed |
| US-7396828-B2 | PI-3 kinase inhibitor prodrugs | SEMAFORE PHARMACEUTICALS, INC. (US) | 2008-07-08 | — | — | US | disclosed |
| EP-1611119-A1 | PI-3 KINASE INHIBITOR PRODRUGS | Semafore Pharmaceuticals, Inc. (US) | 2006-01-04 | — | — | EP | disclosed |
| US-6949537-B2 | PI-3 kinase inhibitor prodrugs | SEMAFORE PHARMACEUTICALS, INC. (US) | 2005-09-27 | — | — | US | disclosed |
| US-20050203173-A1 | PI-3 kinase inhibitor prodrugs | SIGNALRX PHARMACEUTICALS, INC. | 2005-09-15 | — | — | US | disclosed |
| US-20040242631-A1 | PI-3 kinase inhibitor prodrugs | SIGNALRX PHARMACEUTICALS, INC. | 2004-12-02 | — | — | US | disclosed |
| WO-2004089925-A1 | PI-3 KINASE INHIBITOR PRODRUGS | SEMAFORE PHARMACEUTICALS, INC. (US) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203173-A1 | PI-3 kinase inhibitor prodrugs | PI4KA, PI4KB, PI4K2B | ALDH1A1 4399/4885HCAR2 2175/4885TSHR 3974/4885 |
| US-20080188423-A1 | PI-3 KINASE INHIBITOR PRODRUGS | PI4KA, PI4KB, PI4K2B | ALDH1A1 4399/4885HCAR2 2175/4885TSHR 3974/4885 |
| US-20040242631-A1 | PI-3 kinase inhibitor prodrugs | PI4KA, PI4KB, PI4K2B | ALDH1A1 4399/4885HCAR2 2175/4885TSHR 3974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.